2022
Pancreatitis-Associated PRSS1-PRSS2 Haplotype Alters T-Cell Receptor Beta (TRB) Repertoire More Strongly Than PRSS1 Expression
Fu D, Blobner B, Greer P, Lafyatis R, Bellin M, Whitcomb D, Study P, Bellin M, Beilman G, Study G, Brand R, Ohlsen C, Saloman J, Whitcomb D, Park H, Lee K, Paniccia A, Zureikat A, Group N, Alkaade S, Amann S, Anderson M, Banks P, Conwell D, Cote G, Forsmark C, Gardner T, Gelrud A, Guda N, Lewis M, Muniraj T, Papachristou G, Romagnuolo J, Sandhu B, Sherman S, Singh V, Slivka A, Wilcox C, Yadav D. Pancreatitis-Associated PRSS1-PRSS2 Haplotype Alters T-Cell Receptor Beta (TRB) Repertoire More Strongly Than PRSS1 Expression. Gastroenterology 2022, 164: 289-292.e4. PMID: 36191639, PMCID: PMC9892203, DOI: 10.1053/j.gastro.2022.09.036.Peer-Reviewed Original Research
2020
Low serum trypsinogen levels in chronic pancreatitis: Correlation with parenchymal loss, exocrine pancreatic insufficiency, and diabetes but not CT-based cambridge severity scores for fibrosis
Zhan W, Akshintala V, Greer PJ, Greer JB, Alkaade S, Anderson MA, Muniraj T, Papachristou GI, Sandhu BS, Slivka A, Wilcox CM, Bellin MD, Singh VK, Yadav D, Brand RE, Whitcomb DC, Group F. Low serum trypsinogen levels in chronic pancreatitis: Correlation with parenchymal loss, exocrine pancreatic insufficiency, and diabetes but not CT-based cambridge severity scores for fibrosis. Pancreatology 2020, 20: 1368-1378. PMID: 32967795, DOI: 10.1016/j.pan.2020.08.025.Peer-Reviewed Original ResearchConceptsSerum trypsinogen levelsChronic pancreatitisTrypsinogen levelsAcinar cell functionCP patientsParenchymal lossCell functionComplex inflammatory disorderExocrine pancreatic insufficiencyCT-based criteriaNAPS2 studySerum trypsinogenAcinar cell lossSurgical resectionFinal cohortInflammatory cellsInflammatory disordersControl subjectsSeverity scoreClinical managementPancreatic insufficiencyStellate cellsNormal rangeCell lossIslet cells
2012
Common genetic variants in the CLDN2 and PRSS1-PRSS2 loci alter risk for alcohol-related and sporadic pancreatitis
Whitcomb DC, LaRusch J, Krasinskas AM, Klei L, Smith JP, Brand RE, Neoptolemos JP, Lerch MM, Tector M, Sandhu BS, Guda NM, Orlichenko L, Alkaade S, Amann S, Anderson M, Baillie J, Banks P, Conwell D, Coté G, Cotton P, DiSario J, Farrer L, Forsmark C, Johnstone M, Gardner T, Gelrud A, Greenhalf W, Haines J, Hartman D, Hawes R, Lawrence C, Lewis M, Mayerle J, Mayeux R, Melhem N, Money M, Muniraj T, Papachristou G, Pericak-Vance M, Romagnuolo J, Schellenberg G, Sherman S, Simon P, Singh V, Slivka A, Stolz D, Sutton R, Weiss F, Wilcox C, Zarnescu N, Wisniewski S, O'Connell M, Kienholz M, Roeder K, Barmada M, Yadav D, Devlin B. Common genetic variants in the CLDN2 and PRSS1-PRSS2 loci alter risk for alcohol-related and sporadic pancreatitis. Nature Genetics 2012, 44: 1349-1354. PMID: 23143602, PMCID: PMC3510344, DOI: 10.1038/ng.2466.Peer-Reviewed Original Research