2016
Tradeoffs in Introduction Policies for the Anti-Tuberculosis Drug Bedaquiline: A Model-Based Analysis
Kunkel A, Cobelens FG, Cohen T. Tradeoffs in Introduction Policies for the Anti-Tuberculosis Drug Bedaquiline: A Model-Based Analysis. PLOS Medicine 2016, 13: e1002142. PMID: 27727274, PMCID: PMC5058480, DOI: 10.1371/journal.pmed.1002142.Peer-Reviewed Original ResearchConceptsTreatment of tuberculosisMDR-TB treatmentTB treatmentSecondary casesDrug-resistant (XDR) TBResistance patternsLife expectancyMultidrug-resistant TB patientsDrug bedaquilineMDR-TB drugsAnti-tuberculosis drug bedaquilineCulture conversionMDR patientsTB patientsMortality benefitBedaquiline resistanceMedian timeRisk of resistanceTB drugsDecrease transmissionHypothetical cohortSources of heterogeneityDrug interactionsInitial cohortTime of initiation
2012
Assessing spatial heterogeneity of multidrug-resistant tuberculosis in a high-burden country
Jenkins HE, Plesca V, Ciobanu A, Crudu V, Galusca I, Soltan V, Serbulenco A, Zignol M, Dadu A, Dara M, Cohen T. Assessing spatial heterogeneity of multidrug-resistant tuberculosis in a high-burden country. European Respiratory Journal 2012, 42: 1291-1301. PMID: 23100496, PMCID: PMC3800490, DOI: 10.1183/09031936.00111812.Peer-Reviewed Original ResearchConceptsMultidrug-resistant tuberculosisMDR-TB riskMDR-TB risk factorsNational TB surveillance dataMDR-TB incidenceTB surveillance dataMDR-TB casesHigh-burden countriesMDR-TB burdenDistribution of casesTB casesTuberculosis casesRisk of resistanceRisk factorsGreater riskSubstantial geographical variationSurveillance dataAppropriate targetingTesting coverageRiskTuberculosisBurdenHigh percentageLocal mechanismsPatients
2007
Antiviral Resistance and the Control of Pandemic Influenza
Lipsitch M, Cohen T, Murray M, Levin BR. Antiviral Resistance and the Control of Pandemic Influenza. PLOS Medicine 2007, 4: e15. PMID: 17253900, PMCID: PMC1779817, DOI: 10.1371/journal.pmed.0040015.Peer-Reviewed Original ResearchConceptsResistant strainsPandemic influenzaInfluenza pandemicAntiviral resistanceTransmission-reducing measuresNext influenza pandemicAntiviral drug useUse of antiviralsStrains of influenzaSuboptimal vaccinesAntiviral treatmentInfluenza infectionRisk of resistanceDeterministic compartmental modelAntiviral agentsAntiviral drugsPandemic planningDrug useVaccine developmentDrug resistanceControl measuresAntiviralsInfluenzaPandemic spreadPandemic