Nanoparticle delivery of miR-223 to attenuate macrophage fusion
Moore LB, Sawyer AJ, Saucier-Sawyer J, Saltzman WM, Kyriakides TR. Nanoparticle delivery of miR-223 to attenuate macrophage fusion. Biomaterials 2016, 89: 127-135. PMID: 26967647, PMCID: PMC4924476, DOI: 10.1016/j.biomaterials.2016.02.036.Peer-Reviewed Original ResearchConceptsForeign body giant cellsMiR-223 mimicsMiR-223Foreign body responseMacrophage fusionSubsequent cytoskeletal rearrangementMiR microarrayKO miceRole of microRNAsMolecular mediatorsNegative regulatorGiant cellsPrimary macrophagesFusion of macrophagesNovel mediatorPrecise mechanismFusion-competent stateTherapeutic inhibitorsBody responseMacrophagesNanoparticle deliveryImplant modelMediatorsEventual encapsulationPost-transcriptional level