2021
Integrin β3 targeting biomaterial preferentially promotes secretion of bFGF and viability of iPSC-derived vascular smooth muscle cells
Dash BC, Duan K, Kyriakides TR, Hsia HC. Integrin β3 targeting biomaterial preferentially promotes secretion of bFGF and viability of iPSC-derived vascular smooth muscle cells. Biomaterials Science 2021, 9: 5319-5329. PMID: 34190227, DOI: 10.1039/d1bm00162k.Peer-Reviewed Original ResearchMeSH KeywordsBiocompatible MaterialsCells, CulturedFibroblast Growth Factor 2HumansInduced Pluripotent Stem CellsIntegrin beta3Matrix Metalloproteinase 2Muscle, Smooth, VascularConceptsBasic fibroblast growth factorVascular smooth muscle cellsSmooth muscle cellsIntegrin β3Paracrine secretionMuscle cellsGrowth factorSecretion of bFGFMatrix metalloproteinase-2Proangiogenic growth factorsCell viabilityFibroblast growth factorHuman-induced pluripotent stemMetalloproteinase-2Ligand-integrin interactionExtracellular matrix microenvironmentSecretionPossible rolePositive feedback loopPaucity of researchMatrix microenvironmentIntegrin interactionPluripotent stemFibrillar collagenΒ3
1995
Thrombospondin 1 is expressed by proliferating mesangial cells and is up-regulated by PDGF and bFGF in vivo
Hugo C, Pichler R, Meek R, Gordon K, Kyriakides T, Floege J, Bornstein P, Couser W, Johnson R. Thrombospondin 1 is expressed by proliferating mesangial cells and is up-regulated by PDGF and bFGF in vivo. Kidney International 1995, 48: 1846-1856. PMID: 8587244, DOI: 10.1038/ki.1995.483.Peer-Reviewed Original ResearchConceptsAnti-Thy1 antibodyMesangial cell proliferationThrombospondin-1 expressionMesangial cellsThrombospondin-1Anti-Thy1 nephritisCell proliferationAnti-bFGF antibodyExperimental mesangial proliferative nephritisDe novo expressionMesangial proliferative nephritisGlomerular diseaseNormal ratsProliferative nephritisThrombospondin-1 mRNANovo expressionDouble labelingRatsPDGFAntibodiesNephritisBFGFInfusionDiseaseVivo