2022
Treating ‘Septic’ With Enhanced Antibiotics and ‘Arthritis’ by Mitigation of Excessive Inflammation
Kwon HK, Dussik CM, Kim SH, Kyriakides TR, Oh I, Lee FY. Treating ‘Septic’ With Enhanced Antibiotics and ‘Arthritis’ by Mitigation of Excessive Inflammation. Frontiers In Cellular And Infection Microbiology 2022, 12: 897291. PMID: 35755835, PMCID: PMC9218192, DOI: 10.3389/fcimb.2022.897291.Peer-Reviewed Original ResearchConceptsSeptic arthritisBacterial burdenAntibiotic treatmentMurine modelTherapeutic goalsConcurrent antimicrobial therapyDistinct therapeutic goalsGeneration of inflammationMRSA septic arthritisSeptic knee arthritisInflammatory joint conditionsArticular cartilageMitigation of inflammationPost-antibiotic treatmentNovel therapeutic strategiesSeptic arthritis modelArticular cartilage damageEx vivo modelArticular cartilage integrityInflammatory arthritisInhibitors of ERKInflammatory profileMRSA infectionSynovial tissueExcessive inflammation
2021
Locally delivered adjuvant biofilm‐penetrating antibiotics rescue impaired endochondral fracture healing caused by MRSA infection
Cahill SV, Kwon H, Back J, Lee I, Lee S, Alder KD, Hao Z, Yu KE, Dussik CM, Kyriakides T, Lee F. Locally delivered adjuvant biofilm‐penetrating antibiotics rescue impaired endochondral fracture healing caused by MRSA infection. Journal Of Orthopaedic Research® 2021, 39: 402-414. PMID: 33336805, DOI: 10.1002/jor.24965.Peer-Reviewed Original ResearchConceptsHigh-dose rifampinFracture healingMRSA infectionMethicillin-resistant Staphylococcus aureus osteomyelitisColony-forming unitsTissue bacterial loadStaphylococcus aureus osteomyelitisReactive bone formationRadiographic union scaleEndochondral fracture healingBacterial CFU countsPoor callus formationSoft callus formationTibia scoresRifampin therapyDevastating complicationMRSA colonizationClinical efficacyInfected fracturesTibial radiographsTreatment responseMurine modelIntramedullary pinOpen fracturesO stain