2024
Bone-derived extracellular matrix hydrogel from thrombospondin-2 knock-out mice for bone repair
Chen Z, Zhang J, Lee F, Kyriakides T. Bone-derived extracellular matrix hydrogel from thrombospondin-2 knock-out mice for bone repair. Acta Biomaterialia 2024, 186: 85-94. PMID: 39134130, PMCID: PMC11500023, DOI: 10.1016/j.actbio.2024.08.011.Peer-Reviewed Original ResearchECM hydrogelsWild typeBone repairLack of mechanical integrityExtracellular matrixRepair of bone defectsExtracellular matrix hydrogelDecellularized extracellular matrixMurine calvarial defect modelCalvarial defect modelPromote bone repairHuman umbilical vein endothelial cellsMesenchymal stem cellsThrombospondin-2Fabricated hydrogelsBone extracellular matrixNovel hydrogelsMechanical propertiesCollagen fibril assemblyMatrix hydrogelRepair damaged boneDecellularized ECMMechanical integrityHydrogelsInvasion in vitro
2020
The role of extracellular matrix in the pathophysiology of diabetic wounds
Huang Y, Kyriakides TR. The role of extracellular matrix in the pathophysiology of diabetic wounds. Matrix Biology Plus 2020, 6: 100037. PMID: 33543031, PMCID: PMC7852307, DOI: 10.1016/j.mbplus.2020.100037.Peer-Reviewed Original ResearchECM-modifying enzymesExtracellular matrix productionDevelopment of ECMDiabetic woundsStructural proteinsECM moleculesKey ECM moleculesExtracellular matrixMatricellular proteinDiabetes-induced changesMatrix productionImpaired wound healingUlcerated woundsNew insightsProteinImpaired healingTissue dysfunctionTherapeutic strategiesWound healingWoundsHealingEnzyme
2019
Thrombospondin-2 regulates extracellular matrix production, LOX levels, and cross-linking via downregulation of miR-29
Calabro NE, Barrett A, Chamorro-Jorganes A, Tam S, Kristofik NJ, Xing H, Loye AM, Sessa WC, Hansen K, Kyriakides TR. Thrombospondin-2 regulates extracellular matrix production, LOX levels, and cross-linking via downregulation of miR-29. Matrix Biology 2019, 82: 71-85. PMID: 30876926, PMCID: PMC6710120, DOI: 10.1016/j.matbio.2019.03.002.Peer-Reviewed Original ResearchConceptsECM protein productionProtein productionLysyl oxidaseThrombospondin-2MiR-29Matricellular proteinQuantitative proteomics approachLevels of LOXExtracellular matrix productionProteomic approachECM proteinsMajor regulatorECM homeostasisExtracellular matrixMatrix productionProteinCollagen fibrillogenesisMiR-29 expressionFibrillar collagenImportant modulatorDependent processesLOX levelsRegulatorProductionHomeostasis
2017
Improving in vivo outcomes of decellularized vascular grafts via incorporation of a novel extracellular matrix
Kristofik NJ, Qin L, Calabro NE, Dimitrievska S, Li G, Tellides G, Niklason LE, Kyriakides TR. Improving in vivo outcomes of decellularized vascular grafts via incorporation of a novel extracellular matrix. Biomaterials 2017, 141: 63-73. PMID: 28667900, PMCID: PMC5918415, DOI: 10.1016/j.biomaterials.2017.06.025.Peer-Reviewed Original ResearchConceptsUnmodified graftsVascular graftsCoronary bypass proceduresMechanical propertiesMural cell recruitmentBypass proceduresRat aortaMMP levelsCell recruitmentDecreased failure rateGraftPlatelet studiesGraft mechanical propertiesNative vesselsShelf vascular graftsSmall-diameter vascular graftsTime pointsExtracellular matrixDiameter vascular graftsTensile strengthYoung's modulusWT cellsPresent studySuture retentionFailure rate