2022
Dysregulation of TSP2-Rac1-WAVE2 axis in diabetic cells leads to cytoskeletal disorganization, increased cell stiffness, and dysfunction
Xing H, Huang Y, Kunkemoeller B, Dahl P, Muraleetharan O, Malvankar N, Murrell M, Kyriakides T. Dysregulation of TSP2-Rac1-WAVE2 axis in diabetic cells leads to cytoskeletal disorganization, increased cell stiffness, and dysfunction. Scientific Reports 2022, 12: 22474. PMID: 36577792, PMCID: PMC9797577, DOI: 10.1038/s41598-022-26337-1.Peer-Reviewed Original ResearchConceptsCell-derived matricesCell stiffnessFamily verprolin-homologous protein 2Active Rac1Thrombospondin-2Homologous protein 2Less traction forceCytoskeleton organizationExtracellular matrix productionMajor cell populationF-actinCytoskeletal disorganizationRegulatory roleProtein 2Matrix productionCritical functionsECM productionArt microscopy techniquesNew functionsCell populationsSpindle-like shapeRac1Normal fibroblastsFibroblastsWound space
2009
Engineered Molecular Delivery for Control and Enhancement of Transplanted Endothelial Cell Fate in Tissue Engineering
Jay S, Shepherd B, Andrejecsk J, Kyriakides T, Pober J, Saltzman W. Engineered Molecular Delivery for Control and Enhancement of Transplanted Endothelial Cell Fate in Tissue Engineering. 2009, 1: 1-2. DOI: 10.1109/nebc.2009.4967788.Peer-Reviewed Original ResearchTissue engineeringAdvanced tissue engineeringMultifunctional hydrogelsTissue constructsFunctional microvascular networksTransplantation of ECsEndothelial cell fateBiomaterial strategiesAlginate microparticlesVascular endothelial growth factorEndothelial cellsEngineeringHydrogelsCell fateGrowth factorSustained releaseProtein 1Mural cellsMolecular deliveryMonocyte chemoattractant protein-1Cell populationsProtein therapeuticsProtein matrixAngiogenic growth factorsProtein delivery