Featured Publications
Safety, tolerability, and clinical and neural effects of single-dose psilocybin in obsessive–compulsive disorder: protocol for a randomized, double-blind, placebo-controlled, non-crossover trial
Ching T, Grazioplene R, Bohner C, Kichuk S, DePalmer G, D’Amico E, Eilbott J, Jankovsky A, Burke M, Hokanson J, Martins B, Witherow C, Patel P, Amoroso L, Schaer H, Pittenger C, Kelmendi B. Safety, tolerability, and clinical and neural effects of single-dose psilocybin in obsessive–compulsive disorder: protocol for a randomized, double-blind, placebo-controlled, non-crossover trial. Frontiers In Psychiatry 2023, 14: 1178529. PMID: 37181888, PMCID: PMC10166878, DOI: 10.3389/fpsyt.2023.1178529.Peer-Reviewed Original ResearchObsessive-compulsive disorderPrimary endpointPsilocybin effectsNeural effectsRefractory obsessive-compulsive disorderNon-crossover designOpen-label doseStandard care treatmentOpen-label studyVisual analog scale ratingsTreatment of OCDEffects of psilocybinOCD symptomsInstitutional review boardYale-Brown ObsessivePrimary outcomeSingle doseCare treatmentOral psilocybinInformed consentReview boardNeurobiological mechanismsCompulsive ScalePsychological supportTrials
2024
Sexual orientation-themed obsessive-compulsive disorder in a lesbian woman: Phenomenology and implications for affirmative assessment and treatment
Schild S, Moore A, Mattera E, Fitzpatrick M, Entezar T, Fram G, Ching T. Sexual orientation-themed obsessive-compulsive disorder in a lesbian woman: Phenomenology and implications for affirmative assessment and treatment. Psychiatry Research Case Reports 2024, 3: 100211. DOI: 10.1016/j.psycr.2024.100211.Peer-Reviewed Original ResearchSexual identitySexual orientation questionsObsessive-compulsive disorderInternalized homophobiaLesbian womenLGBTQ+ individualsAffirming careSexual orientationHeterosexual samplesCisgender womenAffirmative mannerLGBTQ+Orientation questionsHeterosexual patientsIntrusive doubtsCase exampleIdentityHomophobiaTransgenderWomenDanielleSexualityTherapy proceduresDisordersCommunityMechanisms of therapeutic change after psychedelic treatment in OCD
Maloney G, Ching T, Kichuk S, Pittenger C, Kelmendi B. Mechanisms of therapeutic change after psychedelic treatment in OCD. Psychiatry Research 2024, 336: 115907. PMID: 38615521, PMCID: PMC11190873, DOI: 10.1016/j.psychres.2024.115907.Peer-Reviewed Original ResearchConceptsObsessive-compulsive disorderMechanisms of therapeutic changeAversive eventsImagery rescriptingPsychedelic treatmentPsychotherapeutic treatmentPsychotherapeutic frameworkSymptom reductionTherapeutic changePsychotherapyNegative emotionsPsychological mechanismsCore beliefsPilot dataNovel treatmentRescriptingEmotionsDisordersSymptomsReprocessingTreatmentBeliefsResistance to first-lineIndividualsInterventionCorrigendum: Safety, feasibility, tolerability, and clinical effects of repeated psilocybin dosing combined with non-directive support in the treatment of obsessive-compulsive disorder: protocol for a randomized, waitlist-controlled trial with blinded ratings
Ching T, Amoroso L, Bohner C, D'Amico E, Eilbott J, Entezar T, Fitzpatrick M, Fram G, Grazioplene R, Hokanson J, Jankovsky A, Kichuk S, Martins B, Patel P, Schaer H, Shnayder S, Witherow C, Pittenger C, Kelmendi B. Corrigendum: Safety, feasibility, tolerability, and clinical effects of repeated psilocybin dosing combined with non-directive support in the treatment of obsessive-compulsive disorder: protocol for a randomized, waitlist-controlled trial with blinded ratings. Frontiers In Psychiatry 2024, 15: 1372373. PMID: 38435972, PMCID: PMC10905264, DOI: 10.3389/fpsyt.2024.1372373.Peer-Reviewed Original Research
2022
Single-dose psilocybin for treatment-resistant obsessive-compulsive disorder: A case report
Kelmendi B, Kichuk S, DePalmer G, Maloney G, Ching T, Belser A, Pittenger C. Single-dose psilocybin for treatment-resistant obsessive-compulsive disorder: A case report. Heliyon 2022, 8: e12135. PMID: 36536916, PMCID: PMC9758406, DOI: 10.1016/j.heliyon.2022.e12135.Peer-Reviewed Original ResearchObsessive-compulsive disorderTreatment of OCDPsychedelic treatmentTreatment-resistant obsessive-compulsive disorderRefractory obsessive-compulsive disorderOCD symptomsPsychological effectsSerotonin systemSingle experimental studyRecreational usersBrain serotonin systemTreatment of patientsClassic psychedelicsQuality of lifePsilocybinSymptomatic improvementCase reportClinical dataTherapeutic potentialEmotionsPatientsDisordersTreatmentNumber of conditionsCompulsion
2021
Disgust sensitivity mediates the link between homophobia and sexual orientation obsessive-compulsive symptoms
Ching THW, Rouleau TM, Turner E, Williams MT. Disgust sensitivity mediates the link between homophobia and sexual orientation obsessive-compulsive symptoms. Cognitive Behaviour Therapy 2021, 50: 452-465. PMID: 33475018, DOI: 10.1080/16506073.2020.1861083.Peer-Reviewed Original ResearchConceptsOC symptomsObsessive-compulsive disorderDisgust sensitivityParallel mediation analysisObsessive-compulsive symptomsDisgust responsesIntrusive thoughtsRole of homophobiaMediation analysisCollege studentsHeterosexual college studentsPrevious researchMeasures of homophobiaFuture researchIndividual's lifeCurrent studySexual orientationClinical implicationsHomophobiaAggressionSymptomsResearchConstructsThoughtAttitudes
2020
Association Splitting for Obsessive-Compulsive Disorder: A Systematic Review
Ching T, Jelinek L, Hauschildt M, Williams M. Association Splitting for Obsessive-Compulsive Disorder: A Systematic Review. Current Psychiatry Research And Reviews 2020, 15: 248-260. DOI: 10.2174/2352096512666190912143311.Peer-Reviewed Original ResearchCognitive behavior therapyObsessive-compulsive disorderAssociation splittingSelf-help interventionOCD symptomsFace cognitive behavior therapyStandard cognitive behavior therapySpecific OCD symptomsOCD symptom severityDifferent symptom dimensionsLarge effect sizesLanguage of administrationCognitive techniquesEase of comprehensionSemantic associationsSymptom dimensionsUnwanted intrusionsMajority of participantsSymptom severityComparison groupEffect sizeAppropriate comparison groupsSample characteristicsFuture studiesHigh acceptability
2019
Association Splitting
Ching T, Moritz S, Jelinek L. Association Splitting. 2019, 137-162. DOI: 10.1093/med-psych/9780190624798.003.0005.Peer-Reviewed Original ResearchObsessive-compulsive disorderAssociation splittingCognitive behavior therapy programForm of obsessionsSexual obsessionsTherapy sessionsTherapy programTreatment barriersTherapeutic techniquesResearch evidenceObsessionPragmatic utilityNetwork conceptualizationTherapistsConceptualizationSessionsDisordersClients
2017
Assessing Sexual Orientation Symptoms in Obsessive-Compulsive Disorder: Development and Validation of the Sexual Orientation Obsessions and Reactions Test (SORT)
Williams MT, Ching THW, Tellawi G, Siev J, Dowell J, Schlaudt V, Slimowicz JC, Wetterneck CT. Assessing Sexual Orientation Symptoms in Obsessive-Compulsive Disorder: Development and Validation of the Sexual Orientation Obsessions and Reactions Test (SORT). Behavior Therapy 2017, 49: 715-729. PMID: 30146139, DOI: 10.1016/j.beth.2017.12.005.Peer-Reviewed Original ResearchPedophilia-Themed Obsessive–Compulsive Disorder: Assessment, Differential Diagnosis, and Treatment with Exposure and Response Prevention
Bruce SL, Ching THW, Williams MT. Pedophilia-Themed Obsessive–Compulsive Disorder: Assessment, Differential Diagnosis, and Treatment with Exposure and Response Prevention. Archives Of Sexual Behavior 2017, 47: 389-402. PMID: 28822003, DOI: 10.1007/s10508-017-1031-4.Peer-Reviewed Original ResearchConceptsObsessive-compulsive disorderMental health professionalsResponse preventionPedophilic disorderHealth professionalsIntrusive thoughtsExcessive worryCompulsive disorderAspects of exposureImproper interventionFearDisordersClientsChildrenProfessionalsCommon manifestationDifferential diagnosisSpecific formAnxietyObsessiveWorryPedophiliaCompulsionObsessionSymptoms
2016
Violent obsessions are associated with suicidality in an OCD analog sample of college students
Ching TH, Williams M, Siev J. Violent obsessions are associated with suicidality in an OCD analog sample of college students. Cognitive Behaviour Therapy 2016, 46: 129-140. PMID: 27659199, DOI: 10.1080/16506073.2016.1228084.Peer-Reviewed Original ResearchConceptsObsessive-compulsive disorderDepressive symptomsSymptom severityDepressive symptom severityViolent obsessionsSymptom dimensionsSuicide risk assessmentStrong clinical focusComorbid symptomsSymptomsClinical focusSuicidalityProspective designMore representative samplesOC symptom dimensionsObsessive-Compulsive InventorySeverityRepresentative sampleOC symptomsUnique association
2015
Exploring dimensionality in the contamination-relevant semantic network with simulated obsessions and association splitting
Ching T, Goh W, Tan G. Exploring dimensionality in the contamination-relevant semantic network with simulated obsessions and association splitting. Journal Of Obsessive-Compulsive And Related Disorders 2015, 6: 39-48. DOI: 10.1016/j.jocrd.2015.06.003.Peer-Reviewed Original ResearchObsessive-compulsive disorderAssociation splittingOC symptomsRecognition performanceUnselected undergraduate sampleContamination-related symptomsNew cognitive approachFalse recognition rateSemantic networkSemantic network approachCognitive approachWord listsUndergraduate sampleList typesRecognition confidenceDimensional perspectiveSymptom severityNetwork-based interventionsObsessionPurported mechanismsNetwork approachRigorous researchRecognition rateLure typesAforementioned research