2020
AgRP neurons control compulsive exercise and survival in an activity-based anorexia model
Miletta MC, Iyilikci O, Shanabrough M, Šestan-Peša M, Cammisa A, Zeiss CJ, Dietrich MO, Horvath TL. AgRP neurons control compulsive exercise and survival in an activity-based anorexia model. Nature Metabolism 2020, 2: 1204-1211. PMID: 33106687, DOI: 10.1038/s42255-020-00300-8.Peer-Reviewed Original ResearchConceptsAgRP neuronsActivity-based anorexia modelAgRP neuronal activityVivo fiber photometryFood-restricted miceFood-restricted animalsCompulsive exerciseAnorexia modelHypothalamic agoutiNeuropeptide YExercise volumeFood intakeMouse modelNeuronal activityFiber photometryDaily activationNeuronal circuitsPsychiatric conditionsAnorexia nervosaChemogenetic toolsNeuronsLong-term behavioral impactElevated fat contentVoluntary cessationFat content
2010
Gonadotropin-Releasing Hormone Fibers Contact POMC Neurons in the Hypothalamic Arcuate Nucleus
Sotonyi P, Mezei G, Racz B, Dallman MF, Abizaid A, Horvath TL. Gonadotropin-Releasing Hormone Fibers Contact POMC Neurons in the Hypothalamic Arcuate Nucleus. Reproductive Sciences 2010, 17: 1024-1028. PMID: 20713970, DOI: 10.1177/1933719110378346.Peer-Reviewed Original ResearchConceptsArcuate nucleusGonadotropin-releasing hormone (GnRH) neuronsPOMC cell bodiesEnergy expenditureHypothalamic arcuate nucleusHypothalamic neuronal populationsMelanocyte stimulating hormoneHormone neuronsPOMC neuronsAnorexigenic proopiomelanocortinStimulating hormoneAnatomical proximityAxon terminalsGonadal axisGlucose homeostasisPeripheral signalsNeuronal populationsCell bodiesDirect appositionGnRHEnergy metabolismNeuronsMetabolic stateHormoneProopiomelanocortin
1992
GABAergic and catecholaminergic innervation of mediobasal hypothalamic β-endorphin cells projecting to the medial preoptic area
Horvath TL, Naftolin F, Leranth C. GABAergic and catecholaminergic innervation of mediobasal hypothalamic β-endorphin cells projecting to the medial preoptic area. Neuroscience 1992, 51: 391-399. PMID: 1281529, DOI: 10.1016/0306-4522(92)90323-t.Peer-Reviewed Original ResearchConceptsMedial preoptic areaPreoptic areaHormone-producing cellsArcuate nucleusHypothalamic beta-endorphin neuronsHormone-releasing hormone (LHRH) neuronsBeta-endorphin neuronsDirect estrogen actionHormone-containing neuronsVentromedial arcuate nucleusRetrograde tracer horseradish peroxidasePro-opiomelanocortin (POMC) neuronsCellular estrogen receptorsPro-opiomelanocortin cellsTracer horseradish peroxidaseΒ-endorphin cellsHormone neuronsImmunoreactive neuronsCatecholaminergic innervationCatecholaminergic neuronsRetrograde tracingSynaptic contactsEstrogen actionCatecholamine fibersAxon terminalsBeta-endorphin innervation of dopamine neurons in the rat hypothalamus: a light and electron microscopic double immunostaining study
Horvath TL, Naftolin F, Leranth C. Beta-endorphin innervation of dopamine neurons in the rat hypothalamus: a light and electron microscopic double immunostaining study. Endocrinology 1992, 131: 1547-1555. PMID: 1354605, DOI: 10.1210/endo.131.3.1354605.Peer-Reviewed Original ResearchConceptsDopamine neuronsZona incertaDopamine cellsSynaptic connectionsCell bodiesDouble immunostaining experimentsHypophyseal hormone secretionHypothalamic dopaminergic systemFemale rat brainHypothalamic dopaminergic neuronsDorsomedial hypothalamic nucleusDopamine cell bodiesReceptor-containing cellsDouble immunostaining studiesLight microscopic examinationPutative synaptic connectionsLH releaseDopamine innervationImmunoreactive boutonsPeriventricular areaDopaminergic neuronsPRL secretionSynaptic contactsArcuate nucleusHormone secretion