2012
Limitations in anti-obesity drug development: the critical role of hunger-promoting neurons
Dietrich MO, Horvath TL. Limitations in anti-obesity drug development: the critical role of hunger-promoting neurons. Nature Reviews Drug Discovery 2012, 11: 675-691. PMID: 22858652, DOI: 10.1038/nrd3739.Peer-Reviewed Original ResearchConceptsNPY/AgRP neuronsNegative energy balanceSevere side effectsAgRP neuronsPOMC neuronsPositive energy balanceChronic disordersPeripheral tissuesReactive oxygen speciesSide effectsLong-term positive energy balanceCalorie restrictionAnti-obesity drug developmentBehavioral interventionsIntense behavioral interventionsPro-opiomelanocortin (POMC) neuronsChronic metabolic disorderLong-term treatmentWhite adipose tissueAlternative therapeutic approachAnti-obesity therapiesPromotion of satietyNew drug therapiesPopulations of neuronsHigher brain functions
1998
An Alternate Pathway for Visual Signal Integration into the Hypothalamo-Pituitary Axis: Retinorecipient Intergeniculate Neurons Project to Various Regions of the Hypothalamus and Innervate Neuroendocrine Cells Including Those Producing Dopamine
Horvath TL. An Alternate Pathway for Visual Signal Integration into the Hypothalamo-Pituitary Axis: Retinorecipient Intergeniculate Neurons Project to Various Regions of the Hypothalamus and Innervate Neuroendocrine Cells Including Those Producing Dopamine. Journal Of Neuroscience 1998, 18: 1546-1558. PMID: 9454860, PMCID: PMC6792709, DOI: 10.1523/jneurosci.18-04-01546.1998.Peer-Reviewed Original ResearchConceptsHypothalamo-pituitary axisIntergeniculate leafletNeuroendocrine cellsSuprachiasmatic nucleusHypothalamic dopamine neuronsMedial preoptic areaFenestrated capillariesPopulations of neuronsNeurons projectBilateral enucleationHypothalamic projectionsDistal dendritesRetrograde tracerVentromedial nucleusDopamine neuronsIntraperitoneal injectionProjection sitesPeriventricular nucleusPreoptic areaRetinal fibersTract tracingHypothalamic cellsRetinal axonsSynaptic targetsEfferents
1995
Galanin neurons exhibit estrogen receptor immunoreactivity in the female rat mediobasal hypothalamus
Horvath T, Leranth C, Kalra S, Naftolin F. Galanin neurons exhibit estrogen receptor immunoreactivity in the female rat mediobasal hypothalamus. Brain Research 1995, 675: 321-324. PMID: 7540929, DOI: 10.1016/0006-8993(94)01374-q.Peer-Reviewed Original ResearchConceptsPituitary hormone secretionEstrogen receptorHormone secretionMediobasal hypothalamusEstrogen receptor immunoreactivityHypothalamic luteinizing hormoneArcuate nucleus neuronsRat mediobasal hypothalamusPopulations of neuronsGalanin neuronsReceptor immunoreactivityOvarian steroidsEstrogen effectsNucleus neuronsLuteinizing hormoneFemale ratsHormone releaseGalaninHypothalamusNeuronsVibratome sectionsImmunoreactivityReceptorsHormoneSecretion