2019
Mediation of the Acute Stress Response by the Skeleton
Berger JM, Singh P, Khrimian L, Morgan DA, Chowdhury S, Arteaga-Solis E, Horvath TL, Domingos AI, Marsland AL, Yadav V, Rahmouni K, Gao XB, Karsenty G. Mediation of the Acute Stress Response by the Skeleton. Cell Metabolism 2019, 30: 890-902.e8. PMID: 31523009, PMCID: PMC6834912, DOI: 10.1016/j.cmet.2019.08.012.Peer-Reviewed Original ResearchConceptsStress responseBony vertebratesAcute stress responseBone-derived signalsWild-type animalsGenetic studiesEndocrine mediationAdrenal insufficient patientsVertebratesOsteocalcinSympathetic toneParasympathetic neuronsWildOsteocalcin levelsStressorsTypes of stressorsSelective surgeOsteoblastsInactivationRodentsResponseGlutamateUptake
2013
Maternal and Offspring Pools of Osteocalcin Influence Brain Development and Functions
Oury F, Khrimian L, Denny CA, Gardin A, Chamouni A, Goeden N, Huang YY, Lee H, Srinivas P, Gao XB, Suyama S, Langer T, Mann JJ, Horvath TL, Bonnin A, Karsenty G. Maternal and Offspring Pools of Osteocalcin Influence Brain Development and Functions. Cell 2013, 155: 228-241. PMID: 24074871, PMCID: PMC3864001, DOI: 10.1016/j.cell.2013.08.042.Peer-Reviewed Original ResearchConceptsOsteoblast-derived hormone osteocalcinBrain developmentBone-derived signalsBlood-brain barrierFetal brain developmentInfluences brain developmentBone massNeuronal apoptosisMonoamine neurotransmittersGABA synthesisMemory deficitsNeuroanatomical defectsOffspring poolPostnatal functionMaternal genotypeMetabolic functionsOsteocalcinPowerful regulationBrainMaternal influenceRegulationBrainstemPregnancyHippocampusMidbrain