2021
Age‐related calcium dysregulation linked with tau pathology and impaired cognition in non‐human primates
Datta D, Leslie SN, Wang M, Morozov YM, Yang S, Mentone S, Zeiss C, Duque A, Rakic P, Horvath TL, van Dyck C, Nairn AC, Arnsten AFT. Age‐related calcium dysregulation linked with tau pathology and impaired cognition in non‐human primates. Alzheimer's & Dementia 2021, 17: 920-932. PMID: 33829643, PMCID: PMC8195842, DOI: 10.1002/alz.12325.Peer-Reviewed Original ResearchConceptsTau pathologyCalcium leakTau phosphorylationNeuronal firingAlzheimer's diseaseEarly tau phosphorylationPyramidal cell dendritesSporadic Alzheimer's diseasePrimary cortical neuronsPotential therapeutic targetCognitive performanceAge-related reductionMacaque dorsolateral prefrontal cortexDorsolateral prefrontal cortexNon-human primatesCalcium dysregulationCell dendritesCortical neuronsCalcium-binding proteinsAD biomarkersPathology markersTherapeutic targetAnimal modelsAged monkeysPrefrontal cortex
2004
Direct visual and circadian pathways target neuroendocrine cells in primates
Abizaid A, Horvath B, Keefe DL, Leranth C, Horvath TL. Direct visual and circadian pathways target neuroendocrine cells in primates. European Journal Of Neuroscience 2004, 20: 2767-2776. PMID: 15548220, DOI: 10.1111/j.1460-9568.2004.03737.x.Peer-Reviewed Original ResearchConceptsSuprachiasmatic nucleusRetinal inputNeuroendocrine cellsDirect retinal inputHormone-releasing hormoneNon-human primatesHypothalamic suprachiasmatic nucleusSCN efferentsHypothalamic areaHypothalamic neuronsHypothalamic sitesMonosynaptic pathwayVisual afferentsHypothalamic regulatorGonadal axisHormone releaseNeuroendocrine functionPituitary gonadotropsPhotic modulationNeuronsCircadian pacemakerVervet monkeysPresent studyTracing techniquesCircadian clockLow CA1 Spine Synapse Density is Further Reduced by Castration in Male Non-human Primates
Leranth C, Prange-Kiel J, Frick KM, Horvath TL. Low CA1 Spine Synapse Density is Further Reduced by Castration in Male Non-human Primates. Cerebral Cortex 2004, 14: 503-510. PMID: 15054066, DOI: 10.1093/cercor/bhh012.Peer-Reviewed Original ResearchConceptsSpine synapse densitySynapse densityNon-human primatesSpine synapsesCA1 spine synapse densityPyramidal cell apical dendritesCA1 hippocampal areaCell apical dendritesCA1 stratum radiatumFemale non-human primatesMale non-human primatesMale primatesOrchidectomized animalsApical dendritesCA1 areaDendritic shaftsHippocampal areaStratum radiatumGonadal hormonesControl monkeysMale hippocampusGonadectomized animalsOvariectomized femalesAndrogen hormonesPrimate hippocampus