2018
Metabolic regulation and glucose sensitivity of cortical radial glial cells
Rash BG, Micali N, Huttner AJ, Morozov YM, Horvath TL, Rakic P. Metabolic regulation and glucose sensitivity of cortical radial glial cells. Proceedings Of The National Academy Of Sciences Of The United States Of America 2018, 115: 10142-10147. PMID: 30224493, PMCID: PMC6176632, DOI: 10.1073/pnas.1808066115.Peer-Reviewed Original ResearchConceptsRadial glial cellsGlial cellsRGC fibersCortical radial glial cellsEmbryonic cortical slicesGestational obesityCerebral cortexCortical slicesMetabolic disturbancesCortical neurogenesisMetabolic supportBrain disordersAcute lossMitochondrial transportBrain developmentIntracellular CaPotential mechanismsHyperglycemiaMitochondrial functionGlucose sensitivityMiceStem cellsPrimary stem cellsPhysiological mechanismsCells
2014
Minireview: Metabolism of Female Reproduction: Regulatory Mechanisms and Clinical Implications
Seli E, Babayev E, Collins SC, Nemeth G, Horvath TL. Minireview: Metabolism of Female Reproduction: Regulatory Mechanisms and Clinical Implications. Endocrinology 2014, 28: 790-804. PMID: 24678733, PMCID: PMC4042071, DOI: 10.1210/me.2013-1413.Peer-Reviewed Original ResearchConceptsFemale reproductionPeripheral availabilityMetabolic disturbancesMetabolic hormonesAnorexia nervosaClinical implicationsMetabolic determinantsHuman reproductionEnergy metabolismFemale fertilityMetabolic stateMetabolismCentral processesMellitusObesityHypothalamusRegulatory mechanismsInfertilityHormoneNervosa
2005
Input organization and plasticity of hypocretin neurons Possible clues to obesity’s association with insomnia
Horvath TL, Gao XB. Input organization and plasticity of hypocretin neurons Possible clues to obesity’s association with insomnia. Cell Metabolism 2005, 1: 279-286. PMID: 16054072, DOI: 10.1016/j.cmet.2005.03.003.Peer-Reviewed Original ResearchConceptsHypocretin neuronsSynaptic currentsHypothalamic hypocretin neuronsMore excitatory synapsesOvernight food deprivationElevated food intakeExcitatory synaptic currentsControl of arousalCause of narcolepsyStress-induced plasticityHypocretin levelsLeptin administrationHypocretin cellsHypocretin signalingMetabolic disturbancesObesity associationSynaptic organizationExcitatory synapsesFood intakeInhibitory inputsCell bodiesUnderlying causeNeuronsInput organizationFood deprivation