2011
Differential Acute and Chronic Effects of Leptin on Hypothalamic Astrocyte Morphology and Synaptic Protein Levels
García-Cáceres C, Fuente-Martín E, Burgos-Ramos E, Granado M, Frago LM, Barrios V, Horvath T, Argente J, Chowen JA. Differential Acute and Chronic Effects of Leptin on Hypothalamic Astrocyte Morphology and Synaptic Protein Levels. Endocrinology 2011, 152: 1809-1818. PMID: 21343257, PMCID: PMC3860256, DOI: 10.1210/en.2010-1252.Peer-Reviewed Original ResearchConceptsGlial fibrillary acidic proteinChronic leptin exposureSynaptic inputsAstrocyte morphologyLeptin exposureGFAP levelsGlial structural proteinsSynaptic protein densityChronic leptin administrationAcute leptin treatmentSynaptic protein levelsAdult male ratsCentral leptin resistanceFibrillary acidic proteinLevels 1 hPossible direct effectGlial ensheathingNeonatal overnutritionGlial activationLeptin levelsLeptin administrationHypothalamic neuronsLeptin resistanceLeptin treatmentMale rats
2005
Input organization and plasticity of hypocretin neurons Possible clues to obesity’s association with insomnia
Horvath TL, Gao XB. Input organization and plasticity of hypocretin neurons Possible clues to obesity’s association with insomnia. Cell Metabolism 2005, 1: 279-286. PMID: 16054072, DOI: 10.1016/j.cmet.2005.03.003.Peer-Reviewed Original ResearchConceptsHypocretin neuronsSynaptic currentsHypothalamic hypocretin neuronsMore excitatory synapsesOvernight food deprivationElevated food intakeExcitatory synaptic currentsControl of arousalCause of narcolepsyStress-induced plasticityHypocretin levelsLeptin administrationHypocretin cellsHypocretin signalingMetabolic disturbancesObesity associationSynaptic organizationExcitatory synapsesFood intakeInhibitory inputsCell bodiesUnderlying causeNeuronsInput organizationFood deprivation
2002
Leptin Uptake by Serotonergic Neurones of the Dorsal Raphe
Fernández‐Galaz M, Diano S, Horvath TL, Garcia‐Segura L. Leptin Uptake by Serotonergic Neurones of the Dorsal Raphe. Journal Of Neuroendocrinology 2002, 14: 429-434. PMID: 12047717, DOI: 10.1046/j.1365-2826.2002.00783.x.Peer-Reviewed Original ResearchConceptsEffects of leptinRaphe nucleusDorsal rapheFemale ratsMidbrain serotonergic systemsSerotonergic systemSerotonergic neuronesRaphe neuronesDistribution of neuronesMouse recombinant leptinIntracerebroventricular administrationLeptin administrationLeptin uptakeLeptin treatmentPeriventricular grayMale ratsFood intakeRecombinant leptinLeptinSleep patternsGender differencesBrain functionImportant mediatorLeptin accumulationNeurones