2024
Hypothalamic hormone deficiency enables physiological anorexia in ground squirrels during hibernation
Mohr S, Dai Pra R, Platt M, Feketa V, Shanabrough M, Varela L, Kristant A, Cao H, Merriman D, Horvath T, Bagriantsev S, Gracheva E. Hypothalamic hormone deficiency enables physiological anorexia in ground squirrels during hibernation. Nature Communications 2024, 15: 5803. PMID: 38987241, PMCID: PMC11236985, DOI: 10.1038/s41467-024-49996-2.Peer-Reviewed Original ResearchConceptsHypothalamic feeding centersHormone deficiencyHypothalamic arcuate nucleus neuronsArcuate nucleus neuronsThyroid hormone deficiencyFeeding centerEffects of ghrelinAnorexigenic effectNucleus neuronsPhysiological anorexiaThyroid hormonesNormal physiological functionsGround squirrelsInterbout arousalAnorexiaThirteen-lined ground squirrelsProlonged periodReduced sensitivityPhysiological functionsDeficiency
2016
Comparison of Individual and Combined Effects of Four Endocrine Disruptors on Estrogen Receptor Beta Transcription in Cerebellar Cell Culture: The Modulatory Role of Estradiol and Triiodo-Thyronine
Jocsak G, Kiss DS, Toth I, Goszleth G, Bartha T, Frenyo LV, Horvath TL, Zsarnovszky A. Comparison of Individual and Combined Effects of Four Endocrine Disruptors on Estrogen Receptor Beta Transcription in Cerebellar Cell Culture: The Modulatory Role of Estradiol and Triiodo-Thyronine. International Journal Of Environmental Research And Public Health 2016, 13: 619. PMID: 27338438, PMCID: PMC4924076, DOI: 10.3390/ijerph13060619.Peer-Reviewed Original ResearchConceptsERβ mRNA expressionModulatory roleMRNA expressionCerebellar cell culturesGlial cellsEstrogen receptor β mRNA expressionEndocrine disruptorsAbsence of E2ED effectsPrimary cerebellar cell culturesΒ mRNA expressionAdverse health effectsHormonal milieuBody of evidenceHormone deficiencyCell culturesTriiodo-ThyronineHealth effectsEnvironmental substancesSimultaneous exposureEstradiolComparison of individualsObserved potencyE2T3