2009
Reduced anticipatory locomotor responses to scheduled meals in ghrelin receptor deficient mice
Blum ID, Patterson Z, Khazall R, Lamont EW, Sleeman MW, Horvath TL, Abizaid A. Reduced anticipatory locomotor responses to scheduled meals in ghrelin receptor deficient mice. Neuroscience 2009, 164: 351-359. PMID: 19666088, PMCID: PMC2996828, DOI: 10.1016/j.neuroscience.2009.08.009.Peer-Reviewed Original ResearchConceptsAnticipatory locomotor activityGHSR KO miceLocomotor activityKO miceGhrelin receptor deficient miceReceptor-deficient miceFeeding scheduleFos expression patternsWild-type littermatesRestricted feeding scheduleGhrelin receptor geneGhrelin injectionOrexigenic hormoneFos immunoreactivityHypothalamic nucleiDeficient miceLocomotor responseGhrelinH dailyMiceReceptor geneMealH patternTargeted mutationsBehavioral measures
2004
Central Administration of Ghrelin and Agouti-Related Protein (83–132) Increases Food Intake and Decreases Spontaneous Locomotor Activity in Rats
Tang-Christensen M, Vrang N, Ortmann S, Bidlingmaier M, Horvath TL, Tschöp M. Central Administration of Ghrelin and Agouti-Related Protein (83–132) Increases Food Intake and Decreases Spontaneous Locomotor Activity in Rats. Endocrinology 2004, 145: 4645-4652. PMID: 15231700, DOI: 10.1210/en.2004-0529.Peer-Reviewed Original ResearchConceptsNeuropeptides neuropeptide YFood intakePhysical activityLocomotor activityOrexigenic neuropeptides neuropeptide YCentral administrationSpontaneous physical activitySingle intracerebroventricular injectionMajor etiological factorGH secretagogue receptorSpontaneous locomotor activityOverall locomotor activityDose-dependent mannerNovel peptide hormoneGhrelin injectionIntracerebroventricular injectionHypothalamic neuronsNeuropeptide YSecretagogue receptorEtiological factorsGhrelinHigh doseEndogenous ligandHunger factorAgRP