2015
Developmental programming of hypothalamic neuroendocrine systems
Ralevski A, Horvath TL. Developmental programming of hypothalamic neuroendocrine systems. Frontiers In Neuroendocrinology 2015, 39: 52-58. PMID: 26391503, DOI: 10.1016/j.yfrne.2015.09.002.Peer-Reviewed Original ResearchConceptsHypothalamic neuroendocrine systemsDevelopmental programmingNeuroendocrine systemMetabolic fateMetabolic syndromeHypothalamic circuitsPerinatal environmentPossible cognitive impairmentMetabolic programmingCognitive impairmentMetabolic influencesEnergy homeostasisCritical periodNeural systemsSyndrome
2011
Maternal Ghrelin Deficiency Compromises Reproduction in Female Progeny through Altered Uterine Developmental Programming
Martin JR, Lieber SB, McGrath J, Shanabrough M, Horvath TL, Taylor HS. Maternal Ghrelin Deficiency Compromises Reproduction in Female Progeny through Altered Uterine Developmental Programming. Endocrinology 2011, 152: 2060-2066. PMID: 21325042, PMCID: PMC3075930, DOI: 10.1210/en.2010-1485.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsEmbryo ImplantationFemaleFertilityGene Expression Regulation, DevelopmentalGhrelinHeterozygoteHomeobox A10 ProteinsHomeodomain ProteinsImmunohistochemistryLitter SizeMaleMiceMice, KnockoutProliferating Cell Nuclear AntigenReproductionReverse Transcriptase Polymerase Chain ReactionTranscription FactorsUterusWnt ProteinsConceptsGhrelin deficiencyDevelopmental programmingAbnormal endometrial functionFemale wild-type miceUterus of miceLevels of ghrelinRegulation of appetiteWild-type miceReproductive tract developmentWild-type offspringSubsequent subfertilityEndometrial proliferationUnexposed miceEndometrial functionUtero exposureUterine expressionEmbryo implantationOvarian folliclesCorpora luteaGhrelinReproductive tractTract developmentMiceSignificant alterationsSubfertility
2006
Developmental programming of the hypothalamus: a matter of fat
Horvath TL, Bruning JC. Developmental programming of the hypothalamus: a matter of fat. Nature Medicine 2006, 12: 52-53. PMID: 16397567, DOI: 10.1038/nm0106-52.Peer-Reviewed Original Research