2024
Kisspeptin signaling in astrocytes modulates the reproductive axis
Torres E, Pellegrino G, Granados-Rodríguez M, Fuentes-Fayos A, Velasco I, Coutteau-Robles A, Legrand A, Shanabrough M, Perdices-Lopez C, Leon S, Yeo S, Manchishi S, Sánchez-Tapia M, Navarro V, Pineda R, Roa J, Naftolin F, Argente J, Luque R, Chowen J, Horvath T, Prevot V, Sharif A, Colledge W, Tena-Sempere M, Romero-Ruiz A. Kisspeptin signaling in astrocytes modulates the reproductive axis. Journal Of Clinical Investigation 2024, 134: e172908. PMID: 38861336, PMCID: PMC11291270, DOI: 10.1172/jci172908.Peer-Reviewed Original ResearchResponse to metabolic stressProtein-protein interactionsMetabolic stressOntology analysisReproductive axisKisspeptin signalingGene expressionKisspeptin actionHypothalamic GnRH neuronsProteomic profilingFemale pubertal onsetReproductive modulesExpression of KISS1RLH secretory profilesSignaling-pathwayCellular co-expressionConditional ablationResponse to kisspeptinLH responses to kisspeptinNon-neuronal pathwaysAstrocytes in vivoHigh-fat dietGFAP-positive cellsPathwayReproductive control
2021
Ucp2-dependent microglia-neuronal coupling controls ventral hippocampal circuit function and anxiety-like behavior
Yasumoto Y, Stoiljkovic M, Kim JD, Sestan-Pesa M, Gao XB, Diano S, Horvath TL. Ucp2-dependent microglia-neuronal coupling controls ventral hippocampal circuit function and anxiety-like behavior. Molecular Psychiatry 2021, 26: 2740-2752. PMID: 33879866, PMCID: PMC8056795, DOI: 10.1038/s41380-021-01105-1.Peer-Reviewed Original ResearchConceptsAnxiety-like behaviorReactive oxygen speciesMicroglia-synapse contactsSpine synapse numberHippocampal circuit functionNeuronal circuit dysfunctionMicroglial productionVentral hippocampusCircuit dysfunctionSpine synapsesSynapse numberAdult brainTransient riseMitochondrial ROS generationMicrogliaBrain functionConditional ablationPhagocytic inclusionsSynaptic elementsProtein 2ROS generationSignificant reductionCircuit functionConsequent accumulationOxygen species