2015
Mitochondria in Control of Hypothalamic Metabolic Circuits
Nasrallah C, Horvath T. Mitochondria in Control of Hypothalamic Metabolic Circuits. 2015, 186-202. DOI: 10.1002/9781119017127.ch8.Peer-Reviewed Original ResearchPOMC neuronsNutritional statusBody nutritional statusAgRP neuronsGhrelin increasesLeptin levelsFood intakeCentral regulationGlucose levelsMetabolic disordersNeuronal functionPrimary siteLipid metabolismMetabolic principlesMitochondrial dysfunctionNeuronsCessation of feedingBioenergetic adaptationImportant contributorMitochondrial dynamicsMetabolic circuitsHypothalamusDysfunctionSatietyIntakeHypothalamic POMC neurons promote cannabinoid-induced feeding
Koch M, Varela L, Kim JG, Kim JD, Hernández-Nuño F, Simonds SE, Castorena CM, Vianna CR, Elmquist JK, Morozov YM, Rakic P, Bechmann I, Cowley MA, Szigeti-Buck K, Dietrich MO, Gao XB, Diano S, Horvath TL. Hypothalamic POMC neurons promote cannabinoid-induced feeding. Nature 2015, 519: 45-50. PMID: 25707796, PMCID: PMC4496586, DOI: 10.1038/nature14260.Peer-Reviewed Original ResearchConceptsPOMC neuronsΒ-endorphinHypothalamic pro-opiomelanocortin (POMC) neuronsOpioid peptide β-endorphinHypothalamic POMC neuronsPromotion of feedingPro-opiomelanocortin (POMC) neuronsCannabinoid receptor 1CB1R activityPOMC activitySated miceHormone releaseHypothalamic administrationFood intakeCentral regulationNeuronal activityParadoxical increaseCB1RReceptor 1POMC cellsNeuronsMitochondrial adaptationsDecreased activityPOMC geneUnsuspected role
2014
Mitochondrial dynamics in the central regulation of metabolism
Nasrallah CM, Horvath TL. Mitochondrial dynamics in the central regulation of metabolism. Nature Reviews Endocrinology 2014, 10: 650-658. PMID: 25200564, DOI: 10.1038/nrendo.2014.160.Peer-Reviewed Original ResearchConceptsPOMC neuronsMetabolic disordersPeripheral tissue functionsCentral melanocortin systemMitochondrial dynamicsProopiomelanocortin neuronsAnorexigenic responseOrexigenic responseHypothalamic neuronsCentral regulationMelanocortin systemNeuronsDistinct signaling pathwaysSignaling pathwaysMitochondrial fusionMolecular regulatorsTissue functionDistinct functionsDisordersFatty acidsMetabolismActivationObesityAppetiteResponse
2013
Hypothalamic control of energy balance: insights into the role of synaptic plasticity
Dietrich MO, Horvath TL. Hypothalamic control of energy balance: insights into the role of synaptic plasticity. Trends In Neurosciences 2013, 36: 65-73. PMID: 23318157, DOI: 10.1016/j.tins.2012.12.005.Peer-Reviewed Original ResearchConceptsWhole-body energy metabolismRegion-specific expressionGenetic toolsPeripheral tissue functionsMetabolism regulationMetabolic hormone receptorsEnergy metabolismTissue functionMetabolic eventsRole of neuronsHormone receptorsRegulationGlial cellsHypothalamic controlSynaptic plasticityCentral regulationNeuronal circuitsBrain circuitsEnormous leapPlasticitySurprising findingRoleExpressionMetabolismDynamic process
2012
Ghrelin and the central regulation of feeding and energy balance
Abizaid A, Horvath TL. Ghrelin and the central regulation of feeding and energy balance. Indian Journal Of Endocrinology And Metabolism 2012, 16: 617-626. PMID: 23565498, PMCID: PMC3602992, DOI: 10.4103/2230-8210.105580.Peer-Reviewed Original Research
2004
Brain Circuits Regulating Energy Homeostasis
Horvath TL, Diano S, Tschöp M. Brain Circuits Regulating Energy Homeostasis. The Neuroscientist 2004, 10: 235-246. PMID: 15155062, DOI: 10.1177/1073858403262151.Peer-Reviewed Original Research
2001
Minireview: ghrelin and the regulation of energy balance--a hypothalamic perspective.
Horvath T, Diano S, Sotonyi P, Heiman M, Tschöp M. Minireview: ghrelin and the regulation of energy balance--a hypothalamic perspective. Endocrinology 2001, 142: 4163-9. PMID: 11564668, DOI: 10.1210/endo.142.10.8490.Peer-Reviewed Original ResearchConceptsGH secretionSynthetic ghrelin receptor agonistEnergy homeostasisGhrelin receptor agonistRole of ghrelinEtiology of obesityLeptin actionReceptor agonistClinical trialsChronic changesCentral regulationNeuroendocrine networkGhrelinNutritional stateEnergy deficitImportant regulatorStomachSecretionRecent findingsHomeostasisMost studiesCachexiaObesityHypothalamusPotential significance
1999
Hypocretin (orexin) activation and synaptic innervation of the locus coeruleus noradrenergic system
Horvath T, Peyron C, Diano S, Ivanov A, Aston‐Jones G, Kilduff T, van den Pol A. Hypocretin (orexin) activation and synaptic innervation of the locus coeruleus noradrenergic system. The Journal Of Comparative Neurology 1999, 415: 145-159. PMID: 10545156, DOI: 10.1002/(sici)1096-9861(19991213)415:2<145::aid-cne1>3.0.co;2-2.Peer-Reviewed Original ResearchMeSH KeywordsAction PotentialsAnimalsChlorocebus aethiopsFemaleHypothalamusImmunohistochemistryIntracellular Signaling Peptides and ProteinsLocus CoeruleusMacaca fascicularisMaleMicroscopy, ElectronMSH Release-Inhibiting HormoneNeuropeptidesNeurotransmitter AgentsNorepinephrineOrexinsPresynaptic TerminalsRatsRats, Sprague-DawleyTetrodotoxinTyrosine 3-MonooxygenaseConceptsLocus coeruleusSynaptic innervationNoradrenergic systemAxon terminalsTyrosine hydroxylase-immunopositive cellsAsymmetrical synaptic contactsLC-noradrenergic systemParallel electrophysiological studiesLocus coeruleus noradrenergic systemPresence of tetrodotoxinMelanin-concentrating hormoneLC neuronsAutonomic centersNoradrenergic innervationDense arborizationsExcitatory responsesHypocretin cellsSubstantia nigraSynaptic contactsHypocretin-2Lateral hypothalamusZona incertaModest depolarizationCatecholamine systemsCentral regulationEstrogen receptor β and progesterone receptor mRNA in the intergeniculate leaflet of the female rat
Horvath T, Diano S, Sakamoto H, Shughrue P, Merchenthaler I. Estrogen receptor β and progesterone receptor mRNA in the intergeniculate leaflet of the female rat. Brain Research 1999, 844: 196-200. PMID: 10536277, DOI: 10.1016/s0006-8993(99)01759-x.Peer-Reviewed Original ResearchConceptsLateral geniculate bodyEstrogen receptor betaLateral geniculate nucleusGeniculate bodyIntergeniculate leafletProgesterone receptorGeniculate nucleusReceptor mRNAReceptor betaDorsal lateral geniculate nucleusVentral lateral geniculate nucleusProgesterone receptor mRNAHypothalamic neuroendocrine cellsEstrogen receptor βHormone receptor mRNADifferent limbicHypothalamic sitesFemale ratsCentral regulationReceptor βLabeled cellsNeuroendocrine mechanismsNeuroendocrine cellsEndocrine mechanismsPopulation of cellsSynaptic Interaction between Hypocretin (Orexin) and Neuropeptide Y Cells in the Rodent and Primate Hypothalamus: A Novel Circuit Implicated in Metabolic and Endocrine Regulations
Horvath T, Diano S, van den Pol A. Synaptic Interaction between Hypocretin (Orexin) and Neuropeptide Y Cells in the Rodent and Primate Hypothalamus: A Novel Circuit Implicated in Metabolic and Endocrine Regulations. Journal Of Neuroscience 1999, 19: 1072-1087. PMID: 9920670, PMCID: PMC6782143, DOI: 10.1523/jneurosci.19-03-01072.1999.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCarrier ProteinsChlorocebus aethiopsEndocrine GlandsFemaleHypothalamusIntracellular Signaling Peptides and ProteinsMaleMetabolismNeural PathwaysNeuronsNeuropeptide YNeuropeptidesOrexin ReceptorsOrexinsRatsRats, Sprague-DawleyReceptors, Cell SurfaceReceptors, G-Protein-CoupledReceptors, LeptinReceptors, NeuropeptideSynapsesConceptsHypothalamic functionCentral regulationHypocretin-containing neuronsLateral hypothalamic cellsLeptin receptor immunoreactivityNeuropeptide Y cellsDirect synaptic contactsNeuropeptide Y systemEndocrine regulationEndocrine processesNPY releaseReceptor immunoreactivityExcitatory actionHypocretin cellsSynaptic contactsArcuate nucleusLateral hypothalamusPrimate hypothalamusLeptin receptorSame neuronsHypothalamic cellsSynaptic regulationAdipose tissueHypocretinNPY
1997
Heterogeneity in the neuropeptide Y-containing neurons of the rat arcuate nucleus: GABAergic and non-GABAergic subpopulations
Horvath T, Bechmann I, Naftolin F, Kalra S, Leranth C. Heterogeneity in the neuropeptide Y-containing neurons of the rat arcuate nucleus: GABAergic and non-GABAergic subpopulations. Brain Research 1997, 756: 283-286. PMID: 9187344, DOI: 10.1016/s0006-8993(97)00184-4.Peer-Reviewed Original ResearchConceptsNeuropeptide YArcuate nucleusGlutamic acid decarboxylaseGamma-aminobutyric acidAcid decarboxylaseDorsomedial arcuate nucleusNeuropeptide Y cellsVentral arcuate nucleusAmino acid transmittersHypothalamic arcuate nucleusHypothalamic neuronal populationsRat arcuate nucleusGABAergic neuronsNeuronal perikaryaNeuropeptide Y.Central regulationAppetitive functionsNeuronal populationsY cellsBehavioral effectsDorsomedial aspectNeuronsVibratome sectionsHypothalamusPerikarya