Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) and suicidality: A replication study using reports to the World Health Organization pharmacovigilance database (VigiBase®)
McIntyre R, Mansur R, Rosenblat J, Rhee T, Cao B, Teopiz K, Wong S, Le G, Ho R, Kwan A. Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) and suicidality: A replication study using reports to the World Health Organization pharmacovigilance database (VigiBase®). Journal Of Affective Disorders 2024, 369: 922-927. PMID: 39433133, DOI: 10.1016/j.jad.2024.10.062.Peer-Reviewed Original ResearchGLP-1 RAsReporting Odds RatioFood and Drug AdministrationFDA Adverse Event Reporting SystemGLP-1European Medicines AgencyMeasures of suicidalityWorld Health OrganizationGlucagon-like peptide-1 receptor agonistsGlucagon-like peptide 1 receptor agonistsWorld Health Organization pharmacovigilance databasePeptide-1 receptor agonistsPeptide 1 receptor agonistsUnited States Food and Drug AdministrationRA exposureStates Food and Drug AdministrationSuicidal behaviorSuicidal ideationAdverse Event Reporting SystemSuicideReceptor agonistsEvent Reporting SystemSemaglutideOdds ratioPharmacovigilance databaseAssociation between rumination, suicidal ideation and suicide attempts in persons with depressive and other mood disorders and healthy controls: A systematic review and meta-analysis
Le G, Wong S, Au H, Badulescu S, Gill H, Vasudeva S, Teopiz K, Rhee T, Ho R, Kwan A, Mansur R, Rosenblat J, McIntyre R. Association between rumination, suicidal ideation and suicide attempts in persons with depressive and other mood disorders and healthy controls: A systematic review and meta-analysis. Journal Of Affective Disorders 2024, 368: 513-527. PMID: 39303880, DOI: 10.1016/j.jad.2024.09.118.Peer-Reviewed Original ResearchSuicidal ideationMood disordersPsychiatric disordersLifetime history of suicide attemptsHealthy controlsHistory of suicide attemptsMeasures of ruminationSuicide attempt historyDiagnosed mood disorderTransdiagnostic associationsAttempt historyDepressive disorderNeurobiological substratesSuicide completersLifetime historyGeneral cognitionSuicide attemptsMeta-analysisIdeationSystematic reviewMoodClinically meaningful associationsSuicideResearch vistasFunctional impairment