A hydrophobic gate in the inner pore helix is the major determinant of inactivation in mechanosensitive Piezo channels
Zheng W, Gracheva EO, Bagriantsev SN. A hydrophobic gate in the inner pore helix is the major determinant of inactivation in mechanosensitive Piezo channels. ELife 2019, 8: e44003. PMID: 30628892, PMCID: PMC6349400, DOI: 10.7554/elife.44003.Peer-Reviewed Original ResearchConceptsPiezo channelsLining inner helixIon channelsMechanosensitive Piezo channelsInner pore helixImportance of inactivationMouse Piezo1Disease-causing mutationsHydrophobic gateInner helixPore helixPhysiological processesMechanism of inactivationStimulation triggersInactivationInactivation gatePiezo1Normal functionHelixHydrophobic barrierFast inactivationPhysical constrictionSecondary gateRate of inactivationMajor determinant