2002
Molecular Basis for Species-Specific Sensitivity to “Hot” Chili Peppers
Jordt SE, Julius D. Molecular Basis for Species-Specific Sensitivity to “Hot” Chili Peppers. Cell 2002, 108: 421-430. PMID: 11853675, DOI: 10.1016/s0092-8674(02)00637-2.Peer-Reviewed Original ResearchConceptsMolecular basisSpecies-specific behavioural responsesSpecies-specific sensitivitySeed dispersalMammalian counterpartsChili pepperChicken receptorPredatory mammalsRat vanilloid receptorEcological phenomenaMammalsPain-producing effectsBirdsVanilloid receptorsRecent acquisitionPepperCompound capsaicinReceptorsDispersalBehavioral responsesDomainChickensBasis
1997
Molecular dissection of gating in the ClC‐2 chloride channel
Jordt S, Jentsch T. Molecular dissection of gating in the ClC‐2 chloride channel. The EMBO Journal 1997, 16: 1582-1592. PMID: 9130703, PMCID: PMC1169762, DOI: 10.1093/emboj/16.7.1582.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid SequenceAnimalsCell MembraneChloride ChannelsConsensus SequenceHydrogen-Ion ConcentrationIon Channel GatingMembrane PotentialsModels, StructuralMolecular Sequence DataMutagenesis, Site-DirectedOocytesPatch-Clamp TechniquesPoint MutationProtein Structure, SecondaryRatsRecombinant Fusion ProteinsXenopus laevisConceptsChloride channelsClC-2 chloride channelSite-directed mutagenesisMolecular dissectionEquivalent mutationCytoplasmic loopMode of activationClC-0ClC-2Gating mechanismInactivation domainMutationsCell swellingActivationNeuronal excitabilityMutagenesisTransmembraneCell volumeDeletionRegulationPathwayFinal pathwayMechanismVoltage dependenceOutward rectification