2007
The menthol receptor TRPM8 is the principal detector of environmental cold
Bautista DM, Siemens J, Glazer JM, Tsuruda PR, Basbaum AI, Stucky CL, Jordt SE, Julius D. The menthol receptor TRPM8 is the principal detector of environmental cold. Nature 2007, 448: 204-208. PMID: 17538622, DOI: 10.1038/nature05910.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCold TemperatureFemaleGanglia, SensoryGene TargetingMaleMentholMiceMice, Inbred C57BLThermosensingTRPM Cation ChannelsConceptsMenthol receptor TRPM8TRPM8 knockout miceIntact nerve fibersDifferent ion channelsNerve fibersWhole animal testsKnockout miceNoxious coldCold stimuliCold sensationCold transducerInnocuous coolEnvironmental coldTRPM8MiceIon channelsAnimal testsCellular levelPhysiological importanceCold sensitivity
2006
TRPA1 Mediates the Inflammatory Actions of Environmental Irritants and Proalgesic Agents
Bautista DM, Jordt SE, Nikai T, Tsuruda PR, Read AJ, Poblete J, Yamoah EN, Basbaum AI, Julius D. TRPA1 Mediates the Inflammatory Actions of Environmental Irritants and Proalgesic Agents. Cell 2006, 124: 1269-1282. PMID: 16564016, DOI: 10.1016/j.cell.2006.02.023.Peer-Reviewed Original ResearchConceptsTRPA1-deficient miceInflammatory painEnvironmental irritantsInflammatory actionsProalgesic agentsPrimary afferent nociceptorsExcitatory ion channelPain hypersensitivityPungent irritantsAfferent nociceptorsNociceptor excitationAuditory functionThermal nociceptionNoxious coldMice exhibitChemotherapeutic agentsTRPA1PainIrritantsNociceptorsMiceSole targetMustard oilIon channelsInitial detection