2020
Transient receptor potential channels in pulmonary chemical injuries and as countermeasure targets
Achanta S, Jordt S. Transient receptor potential channels in pulmonary chemical injuries and as countermeasure targets. Annals Of The New York Academy Of Sciences 2020, 1480: 73-103. PMID: 32892378, PMCID: PMC7933981, DOI: 10.1111/nyas.14472.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCalciumCalcium SignalingChemical Warfare AgentsHumansLungLung InjuryTRPA1 Cation ChannelTRPV Cation ChannelsConceptsChemical injuryTRP channelsNeurogenic inflammatory pathwaysChemical threat agentsMediator of injuryTransient receptor potential channelsTransient receptor potential (TRP) ion channelsIntracellular calcium levelsToxic inhalation hazardPotential ion channelsCough reflexPulmonary injuryPulmonary edemaProinflammatory cellsInflammatory pathwaysPathophysiologic eventsOccupational exposureMucus clearanceCalcium levelsInjuryNonneuronal pathwaysRespiratory systemBroader indicationsPotential channelsInhalation hazard
2018
Formation of flavorant–propylene Glycol Adducts With Novel Toxicological Properties in Chemically Unstable E-Cigarette Liquids
Erythropel HC, Jabba SV, DeWinter TM, Mendizabal M, Anastas PT, Jordt SE, Zimmerman JB. Formation of flavorant–propylene Glycol Adducts With Novel Toxicological Properties in Chemically Unstable E-Cigarette Liquids. Nicotine & Tobacco Research 2018, 21: 1248-1258. PMID: 30335174, PMCID: PMC6698951, DOI: 10.1093/ntr/nty192.Peer-Reviewed Original ResearchConceptsFlavor aldehydesSolvent componentsNuclear magnetic resonance spectroscopyNovel chemical speciesReaction productsPhysiological aqueous solutionE-cigarette liquidsReactive chemical systemsToxicological propertiesCommercial e-liquidsMagnetic resonance spectroscopyE-liquidsAqueous mediaPropylene glycolAqueous solutionPotential toxicological effectsNew compoundsUltraviolet spectroscopyChemical speciesChemical reactionsGas chromatographyChemical systemsResonance spectroscopyToxicological effectsAldehydes
2017
Ankyrin‐rich membrane spanning protein as a novel modulator of transient receptor potential vanilloid 1‐function in nociceptive neurons
Peter J, Kasper C, Kaufholz M, Buschow R, Isensee J, Hucho T, Herberg F, Schwede F, Stein C, Jordt S, Brackmann M, Spahn V. Ankyrin‐rich membrane spanning protein as a novel modulator of transient receptor potential vanilloid 1‐function in nociceptive neurons. European Journal Of Pain 2017, 21: 1072-1086. PMID: 28182310, PMCID: PMC5504413, DOI: 10.1002/ejp.1008.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCapsaicinCyclic AMP-Dependent Protein KinasesGanglia, SpinalHEK293 CellsHumansMembrane ProteinsMiceNociceptorsTRPV Cation ChannelsConceptsAnkyrin-rich membranePKA-dependent mannerKinase DHEK-293 cellsSensitivity of TRPV1Immunoprecipitation experimentsDRG neuronsNovel modulatorRodent DRG neuronsIon channelsIon channel TRPV1Excitatory ion channelSmall-diameter dorsal root ganglion neuronsTransient receptor potential vanilloidImportant componentDorsal root ganglion neuronsPeripheral sensory neuronsMouse DRG neuronsChemical stimuliSensory neuronsCellsComplexesMembraneDirect modificationTRPV1 expression
2016
Tear gas: an epidemiological and mechanistic reassessment
Rothenberg C, Achanta S, Svendsen ER, Jordt S. Tear gas: an epidemiological and mechanistic reassessment. Annals Of The New York Academy Of Sciences 2016, 1378: 96-107. PMID: 27391380, PMCID: PMC5096012, DOI: 10.1111/nyas.13141.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCardiovascular DiseasesHumansNervous System DiseasesRespiration DisordersTear GasesTransient Receptor Potential ChannelsTRPV Cation ChannelsConceptsTear gas agentsPeripheral sensory neuronsRecent epidemiological studiesIon channel TRPV1Lung injuryChronic morbidityOcular injuriesChronic painHigh riskSensory neuronsEpidemiological studiesAnimal modelsGas injuryInjuryPromising effectsMechanistic researchTRPV1Pepper sprayTRPA1Health risksTear gasRiskCivilian populationPotential inhibitorsCough
2008
Breathtaking TRP Channels: TRPA1 and TRPV1 in Airway Chemosensation and Reflex Control
Bessac BF, Jordt SE. Breathtaking TRP Channels: TRPA1 and TRPV1 in Airway Chemosensation and Reflex Control. Physiology 2008, 23: 360-370. PMID: 19074743, PMCID: PMC2735846, DOI: 10.1152/physiol.00026.2008.Peer-Reviewed Original ResearchConceptsReactive airways dysfunction syndromeAirway reflex responsesAirways dysfunction syndromeAirway inflammationChronic coughDysfunction syndromeTRP ion channelsReflex responsesReflex controlCapsaicin receptorChemical hypersensitivityTRPA1Reactive oxygen speciesInflammationTRPV1Noxious constituentsIon channelsOxygen speciesNew studiesCOPDCoughAsthmaSyndromeHypersensitivityIrritation
2007
Trp Channels In Disease
JORDT SE, EHRLICH BE. Trp Channels In Disease. Subcellular Biochemistry 2007, 45: 253-271. PMID: 18193640, DOI: 10.1007/978-1-4020-6191-2_9.Peer-Reviewed Original ResearchConceptsTRP channelsTransient receptor potential channelsPainful stimuliTRPA (ankyrin) groupsRole of TrpIntracellular Ca2Intracellular storesTRP channel physiologyDiseaseNormal physiologyChannel physiologySpecific diseasesPathophysiologyPotential channelsDifferent TRPsExtracellular stimuliMain subfamiliesDistinct functionsChemical signalsStimuliPhysiologyLarge familyMutationsProgression
2000
Acid potentiation of the capsaicin receptor determined by a key extracellular site
Jordt S, Tominaga M, Julius D. Acid potentiation of the capsaicin receptor determined by a key extracellular site. Proceedings Of The National Academy Of Sciences Of The United States Of America 2000, 97: 8134-8139. PMID: 10859346, PMCID: PMC16682, DOI: 10.1073/pnas.100129497.Peer-Reviewed Original Research