TRPA1 controls inflammation and pruritogen responses in allergic contact dermatitis
Liu B, Escalera J, Balakrishna S, Fan L, Caceres A, Robinson E, Sui A, McKay M, McAlexander M, Herrick C, Jordt S. TRPA1 controls inflammation and pruritogen responses in allergic contact dermatitis. The FASEB Journal 2013, 27: 3549-3563. PMID: 23722916, PMCID: PMC3752543, DOI: 10.1096/fj.13-229948.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsDermatitis, Allergic ContactFemaleInflammationMaleMiceMice, Inbred C57BLMice, KnockoutOxazoloneTransient Receptor Potential ChannelsTRPA1 Cation ChannelConceptsAllergic contact dermatitisSubstance PScratching behaviorContact dermatitisSensory neuronsSP receptor antagonistTRPA1-deficient miceCommon skin diseaseChronic inflammatory responseTransient receptor potential (TRP) ion channelsNerve growth factorPotential ion channelsEndogenous pruritogensPruritic responsesPersistent pruritusCutaneous inflammationLeukocyte infiltrationInflammatory cytokinesSkin edemaReceptor antagonistAllergic responsesContact allergensInflammatory responseKeratinocyte hyperplasiaSP signaling