2004
Mustard oils and cannabinoids excite sensory nerve fibres through the TRP channel ANKTM1
Jordt SE, Bautista DM, Chuang HH, McKemy DD, Zygmunt PM, Högestätt ED, Meng ID, Julius D. Mustard oils and cannabinoids excite sensory nerve fibres through the TRP channel ANKTM1. Nature 2004, 427: 260-265. PMID: 14712238, DOI: 10.1038/nature02282.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAnimals, NewbornAnkyrinsCalcium ChannelsCalcium SignalingCannabinoidsCapsaicinCarbacholCells, CulturedCloning, MolecularDronabinolHumansMustard PlantNerve Tissue ProteinsNeurons, AfferentNociceptorsOocytesPlant OilsRatsRats, Sprague-DawleyRNA, MessengerThapsigarginTransient Receptor Potential ChannelsTrigeminal GanglionTRPA1 Cation ChannelTRPC Cation ChannelsConceptsMustard oilPrimary sensory neuronsSensory nerve fibersSensory nerve endingsTRP ion channel familyExcitatory effectsNerve endingsNerve fibersIon channel familyPungent ingredientSensory neuronsTopical applicationPsychoactive componentΔ9-tetrahydrocannabinolTRP channelsMolecular targetsANKTM1Channel familyMolecular mechanismsAllyl isothiocyanatePainInflammationWidespread useCapsaicinHypersensitivity
1998
Characterization of the hyperpolarization‐activated chloride current in dissociated rat sympathetic neurons
Clark S, Jordt S, Jentsch T, Mathie A. Characterization of the hyperpolarization‐activated chloride current in dissociated rat sympathetic neurons. The Journal Of Physiology 1998, 506: 665-678. PMID: 9503329, PMCID: PMC2230754, DOI: 10.1111/j.1469-7793.1998.665bv.x.Peer-Reviewed Original ResearchConceptsSCG neuronsRat superior cervical ganglion neuronsChloride currentsSuperior cervical ganglion neuronsConventional whole-cell recordingRat SCG neuronsClC-2Rat cerebellar granule cellsRat sympathetic neuronsPerforated-patch recordingsWhole-cell recordingsHyperpolarization-activated chloride currentCerebellar granule cellsTranscriptase-polymerase chain reaction experimentsPresence of mRNAGanglion neuronsSympathetic neuronsGABAA receptorsMM cesiumGranule cellsEffective blockerExternal potassium concentrationCl- currentInternal chloride concentrationHyperpolarization-activated Cl- current