2009
A sensory neuronal ion channel essential for airway inflammation and hyperreactivity in asthma
Caceres AI, Brackmann M, Elia MD, Bessac BF, del Camino D, D'Amours M, Witek JS, Fanger CM, Chong JA, Hayward NJ, Homer RJ, Cohn L, Huang X, Moran MM, Jordt SE. A sensory neuronal ion channel essential for airway inflammation and hyperreactivity in asthma. Proceedings Of The National Academy Of Sciences Of The United States Of America 2009, 106: 9099-9104. PMID: 19458046, PMCID: PMC2684498, DOI: 10.1073/pnas.0900591106.Peer-Reviewed Original ResearchConceptsAsthmatic airway inflammationAirway inflammationAirway hyperreactivityAllergen challengeHC-030031Airway allergen challengeEndogenous TRPA1 agonistsMurine ovalbumin modelImpaired inflammatory responseTreatment of asthmaRole of TRPA1Wild-type miceAirway epithelial functionAllergic inflammatory conditionsPromising pharmacological targetNeuronal ion channelsLipid peroxidation productsIon channelsAllergic asthmaAirway exposureEosinophil infiltrationLeukocyte infiltrationContractile stimuliInflammatory disordersOvalbumin model
2007
Trp Channels In Disease
JORDT SE, EHRLICH BE. Trp Channels In Disease. Subcellular Biochemistry 2007, 45: 253-271. PMID: 18193640, DOI: 10.1007/978-1-4020-6191-2_9.Peer-Reviewed Original ResearchConceptsTRP channelsTransient receptor potential channelsPainful stimuliTRPA (ankyrin) groupsRole of TrpIntracellular Ca2Intracellular storesTRP channel physiologyDiseaseNormal physiologyChannel physiologySpecific diseasesPathophysiologyPotential channelsDifferent TRPsExtracellular stimuliMain subfamiliesDistinct functionsChemical signalsStimuliPhysiologyLarge familyMutationsProgression