2011
Menthol attenuates respiratory irritation responses to multiple cigarette smoke irritants
Willis DN, Liu B, Ha MA, Jordt S, Morris JB. Menthol attenuates respiratory irritation responses to multiple cigarette smoke irritants. The FASEB Journal 2011, 25: 4434-4444. PMID: 21903934, PMCID: PMC3236628, DOI: 10.1096/fj.11-188383.Peer-Reviewed Original ResearchConceptsTransient receptor potential ankyrin 1Irritation responseMenthol effectsCold-sensitive sensory neuronsSensory TRP channelsSmoking-related morbiditySensory irritation responseEffect of mentholTransient receptor potential melastatin 8 (TRPM8) ion channelActivation of TRPM8TRPM8 agonistTRPM8 antagonistsCapsaicin receptorRespiratory tractSensory neuronsAnkyrin 1Pharmacological actionsNicotine addictionSmoking behaviorRespiratory irritationTRP channelsAgonistsSmoke constituentsAvailable cigarettesCigarettes
2009
A sensory neuronal ion channel essential for airway inflammation and hyperreactivity in asthma
Caceres AI, Brackmann M, Elia MD, Bessac BF, del Camino D, D'Amours M, Witek JS, Fanger CM, Chong JA, Hayward NJ, Homer RJ, Cohn L, Huang X, Moran MM, Jordt SE. A sensory neuronal ion channel essential for airway inflammation and hyperreactivity in asthma. Proceedings Of The National Academy Of Sciences Of The United States Of America 2009, 106: 9099-9104. PMID: 19458046, PMCID: PMC2684498, DOI: 10.1073/pnas.0900591106.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAsthmaBronchial HyperreactivityImmune SystemInflammationMiceMice, KnockoutSensory Receptor CellsTransient Receptor Potential ChannelsTRPA1 Cation ChannelConceptsAsthmatic airway inflammationAirway inflammationAirway hyperreactivityAllergen challengeHC-030031Airway allergen challengeEndogenous TRPA1 agonistsMurine ovalbumin modelImpaired inflammatory responseTreatment of asthmaRole of TRPA1Wild-type miceAirway epithelial functionAllergic inflammatory conditionsPromising pharmacological targetNeuronal ion channelsLipid peroxidation productsIon channelsAllergic asthmaAirway exposureEosinophil infiltrationLeukocyte infiltrationContractile stimuliInflammatory disordersOvalbumin model