2023
Transient Receptor Potential channels (TRP) in GtoPdb v.2023.3
Blair N, Caceres A, Carvacho I, Chaudhuri D, Clapham D, De Clerq K, Delling M, Doerner J, Fan L, Grimm C, Ha K, Hu M, Jabba S, Jordt S, Julius D, Kahle K, Liu B, Liu Q, McKemy D, Nilius B, Oancea E, Owsianik G, Riccio A, Sah R, Stotz S, Tian J, Tong D, Vriens J, Wu L, Xu H, Yang F, Yang W, Yue L, Zhu M. Transient Receptor Potential channels (TRP) in GtoPdb v.2023.3. IUPHAR/BPS Guide To Pharmacology CITE 2023, 2023 DOI: 10.2218/gtopdb/f78/2023.3.Peer-Reviewed Original ResearchTRPC channelsTransient receptor potential channelsCongenital stationary night blindnessCalcium-activated cationStore-operated channelsAdenosine diphosphate riboseNumerous splice variantsNMDA receptorsActivate TRPA1Cation channelsIntracellular ATP levelsChannel activityMicromolar concentrations of La3+Neurodegenerative disorder mucolipidosis type IVDepletion of intracellular calcium storesMucolipidosis type IVTRP channelsRegulation of Ca2+ entryAssociated with conduction defectsDetection of noxious heatDevelopment of heat hyperalgesiaDevelopment of thermal hyperalgesiaDynamic intracellular vesicular structuresExtra-synaptic NMDA receptorsInvolvement of TRP channelsTransient Receptor Potential channels (TRP) in GtoPdb v.2023.2
Blair N, Caceres A, Carvacho I, Chaudhuri D, Clapham D, De Clerq K, Delling M, Doerner J, Fan L, Grimm C, Ha K, Hu M, Jabba S, Jordt S, Julius D, Kahle K, Liu B, Liu Q, McKemy D, Nilius B, Oancea E, Owsianik G, Riccio A, Sah R, Stotz S, Tian J, Tong D, Vriens J, Wu L, Xu H, Yang F, Yang W, Yue L, Zhu M. Transient Receptor Potential channels (TRP) in GtoPdb v.2023.2. IUPHAR/BPS Guide To Pharmacology CITE 2023, 2023 DOI: 10.2218/gtopdb/f78/2023.2.Peer-Reviewed Original ResearchTransient receptor potential channelsCongenital stationary night blindnessTRPC channelsAdenosine diphosphate riboseStore-operated channelsMost TRP channelsTRP channelsNMDA receptorsCation channelsIntracellular ATP levelsExtra-synaptic NMDA receptorsMetabotropic glutamate receptor 6Activation of GoHuman TRPM1 mutationsReabsorption of calciumTRPC4/C5Ion channelsExpression of S100A9Dendritic cell migrationBile duct diseaseIntracellular calcium storesActivity of TRPV1Layer 5 neuronsSynaptic NMDA receptorsMouse prefrontal cortexTransient Receptor Potential channels (TRP) in GtoPdb v.2023.1
Blair N, Carvacho I, Chaudhuri D, Clapham D, De Clerq K, Delling M, Doerner J, Fan L, Grimm C, Ha K, Hu M, Jordt S, Julius D, Kahle K, Liu B, Liu Q, McKemy D, Nilius B, Oancea E, Owsianik G, Riccio A, Sah R, Stotz S, Tian J, Tong D, Vriens J, Wu L, Xu H, Yang F, Yang W, Yue L, Zhu M. Transient Receptor Potential channels (TRP) in GtoPdb v.2023.1. IUPHAR/BPS Guide To Pharmacology CITE 2023, 2023 DOI: 10.2218/gtopdb/f78/2023.1.Peer-Reviewed Original ResearchTransient receptor potential channelsCongenital stationary night blindnessTRPC channelsAdenosine diphosphate riboseStore-operated channelsMost TRP channelsTRP channelsNMDA receptorsCation channelsIntracellular ATP levelsExtra-synaptic NMDA receptorsMetabotropic glutamate receptor 6Activation of GoHuman TRPM1 mutationsReabsorption of calciumTRPC4/C5Ion channelsExpression of S100A9Dendritic cell migrationBile duct diseaseIntracellular calcium storesActivity of TRPV1Layer 5 neuronsSynaptic NMDA receptorsMouse prefrontal cortex
2022
Transient Receptor Potential channels (TRP) in GtoPdb v.2022.1
Blair N, Carvacho I, Chaudhuri D, Clapham D, DeCaen P, Delling M, Doerner J, Fan L, Grimm C, Ha K, Jordt S, Julius D, Kahle K, Liu B, McKemy D, Nilius B, Oancea E, Owsianik G, Riccio A, Sah R, Stotz S, Tian J, Tong D, Van den Eynde C, Vriens J, Wu L, Xu H, Yue L, Zhang X, Zhu M. Transient Receptor Potential channels (TRP) in GtoPdb v.2022.1. IUPHAR/BPS Guide To Pharmacology CITE 2022, 2022 DOI: 10.2218/gtopdb/f78/2022.1.Peer-Reviewed Original ResearchTransient receptor potential channelsCongenital stationary night blindnessTRPC channelsStore-operated channelsMost TRP channelsTRP channelsCation channelsMetabotropic glutamate receptor 6Activation of GoHuman TRPM1 mutationsReabsorption of calciumTRPC4/C5Ion channelsDendritic cell migrationLow extracellular sodiumIntracellular calcium storesActivity of TRPV1Layer 5 neuronsMouse prefrontal cortexMucolipidosis type IVGlutamate receptor 6Store-operated mechanismsMain olfactory epitheliumBroad-spectrum agentsPancreatic beta cells
2021
Transient Receptor Potential channels (TRP) in GtoPdb v.2021.3
Blair N, Carvacho I, Chaudhuri D, Clapham D, DeCaen P, Delling M, Doerner J, Fan L, Ha K, Jordt S, Julius D, Kahle K, Liu B, McKemy D, Nilius B, Oancea E, Owsianik G, Riccio A, Sah R, Stotz S, Tian J, Tong D, Van den Eynde C, Vriens J, Wu L, Xu H, Yue L, Zhang X, Zhu M. Transient Receptor Potential channels (TRP) in GtoPdb v.2021.3. IUPHAR/BPS Guide To Pharmacology CITE 2021, 2021 DOI: 10.2218/gtopdb/f78/2021.3.Peer-Reviewed Original ResearchTransient receptor potential channelsCongenital stationary night blindnessTRPC channelsStore-operated channelsMost TRP channelsTRP channelsCation channelsMetabotropic glutamate receptor 6Activation of GoHuman TRPM1 mutationsReabsorption of calciumTRPC4/C5Ion channelsDendritic cell migrationLow extracellular sodiumIntracellular calcium storesActivity of TRPV1Layer 5 neuronsMouse prefrontal cortexMucolipidosis type IVGlutamate receptor 6Main olfactory epitheliumStore-operated mechanismsBroad-spectrum agentsPancreatic beta cells
2020
Transient receptor potential channels in pulmonary chemical injuries and as countermeasure targets
Achanta S, Jordt S. Transient receptor potential channels in pulmonary chemical injuries and as countermeasure targets. Annals Of The New York Academy Of Sciences 2020, 1480: 73-103. PMID: 32892378, PMCID: PMC7933981, DOI: 10.1111/nyas.14472.Peer-Reviewed Original ResearchConceptsChemical injuryTRP channelsNeurogenic inflammatory pathwaysChemical threat agentsMediator of injuryTransient receptor potential channelsTransient receptor potential (TRP) ion channelsIntracellular calcium levelsToxic inhalation hazardPotential ion channelsCough reflexPulmonary injuryPulmonary edemaProinflammatory cellsInflammatory pathwaysPathophysiologic eventsOccupational exposureMucus clearanceCalcium levelsInjuryNonneuronal pathwaysRespiratory systemBroader indicationsPotential channelsInhalation hazard
2019
Transient Receptor Potential channels (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database
Blair N, Carvacho I, Chaudhuri D, Clapham D, DeCaen P, Delling M, Doerner J, Fan L, Ha K, Jordt S, Julius D, Kahle K, Liu B, McKemy D, Nilius B, Oancea E, Owsianik G, Riccio A, Sah R, Stotz S, Tian J, Tong D, Van den Eynde C, Vriens J, Wu L, Xu H, Yue L, Zhang X, Zhu M. Transient Receptor Potential channels (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database. IUPHAR/BPS Guide To Pharmacology CITE 2019, 2019 DOI: 10.2218/gtopdb/f78/2019.4.Peer-Reviewed Original ResearchCongenital stationary night blindnessTRPC channelsStore-operated channelsMost TRP channelsTRP channelsCation channelsMetabotropic glutamate receptor 6Activation of GoHuman TRPM1 mutationsReabsorption of calciumTRPC4/C5Ion channelsDendritic cell migrationIntracellular calcium storesLow extracellular sodiumLayer 5 neuronsTransient receptor potential channelsActivity of TRPV1Mouse prefrontal cortexMucolipidosis type IVGlutamate receptor 6Main olfactory epitheliumStore-operated mechanismsBroad-spectrum agentsPancreatic beta cells
2011
Menthol attenuates respiratory irritation responses to multiple cigarette smoke irritants
Willis DN, Liu B, Ha MA, Jordt S, Morris JB. Menthol attenuates respiratory irritation responses to multiple cigarette smoke irritants. The FASEB Journal 2011, 25: 4434-4444. PMID: 21903934, PMCID: PMC3236628, DOI: 10.1096/fj.11-188383.Peer-Reviewed Original ResearchConceptsTransient receptor potential ankyrin 1Irritation responseMenthol effectsCold-sensitive sensory neuronsSensory TRP channelsSmoking-related morbiditySensory irritation responseEffect of mentholTransient receptor potential melastatin 8 (TRPM8) ion channelActivation of TRPM8TRPM8 agonistTRPM8 antagonistsCapsaicin receptorRespiratory tractSensory neuronsAnkyrin 1Pharmacological actionsNicotine addictionSmoking behaviorRespiratory irritationTRP channelsAgonistsSmoke constituentsAvailable cigarettesCigarettes
2007
Trp Channels In Disease
JORDT SE, EHRLICH BE. Trp Channels In Disease. Subcellular Biochemistry 2007, 45: 253-271. PMID: 18193640, DOI: 10.1007/978-1-4020-6191-2_9.Peer-Reviewed Original ResearchConceptsTRP channelsTransient receptor potential channelsPainful stimuliTRPA (ankyrin) groupsRole of TrpIntracellular Ca2Intracellular storesTRP channel physiologyDiseaseNormal physiologyChannel physiologySpecific diseasesPathophysiologyPotential channelsDifferent TRPsExtracellular stimuliMain subfamiliesDistinct functionsChemical signalsStimuliPhysiologyLarge familyMutationsProgression
2004
Mustard oils and cannabinoids excite sensory nerve fibres through the TRP channel ANKTM1
Jordt SE, Bautista DM, Chuang HH, McKemy DD, Zygmunt PM, Högestätt ED, Meng ID, Julius D. Mustard oils and cannabinoids excite sensory nerve fibres through the TRP channel ANKTM1. Nature 2004, 427: 260-265. PMID: 14712238, DOI: 10.1038/nature02282.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAnimals, NewbornAnkyrinsCalcium ChannelsCalcium SignalingCannabinoidsCapsaicinCarbacholCells, CulturedCloning, MolecularDronabinolHumansMustard PlantNerve Tissue ProteinsNeurons, AfferentNociceptorsOocytesPlant OilsRatsRats, Sprague-DawleyRNA, MessengerThapsigarginTransient Receptor Potential ChannelsTrigeminal GanglionTRPA1 Cation ChannelTRPC Cation ChannelsConceptsMustard oilPrimary sensory neuronsSensory nerve fibersSensory nerve endingsTRP ion channel familyExcitatory effectsNerve endingsNerve fibersIon channel familyPungent ingredientSensory neuronsTopical applicationPsychoactive componentΔ9-tetrahydrocannabinolTRP channelsMolecular targetsANKTM1Channel familyMolecular mechanismsAllyl isothiocyanatePainInflammationWidespread useCapsaicinHypersensitivity