2005
Pungent products from garlic activate the sensory ion channel TRPA1
Bautista DM, Movahed P, Hinman A, Axelsson HE, Sterner O, Högestätt ED, Julius D, Jordt SE, Zygmunt PM. Pungent products from garlic activate the sensory ion channel TRPA1. Proceedings Of The National Academy Of Sciences Of The United States Of America 2005, 102: 12248-12252. PMID: 16103371, PMCID: PMC1189336, DOI: 10.1073/pnas.0505356102.Peer-Reviewed Original ResearchConceptsSensory nerve endingsSensory neuronsNerve endingsTRPA1 channelsDiallyl disulfidePrimary sensory neuronsActivation of TRPA1Ion channel TRPA1Excitatory ion channelPain pathwaysPungent ingredientAllium familyVasorelaxant activityTRPA1Health benefitsNeuronsAllium extractsIon channelsAllicinMolecular mechanismsAllyl isothiocyanateEndingsPainVasodilationInflammation
2004
Mustard oils and cannabinoids excite sensory nerve fibres through the TRP channel ANKTM1
Jordt SE, Bautista DM, Chuang HH, McKemy DD, Zygmunt PM, Högestätt ED, Meng ID, Julius D. Mustard oils and cannabinoids excite sensory nerve fibres through the TRP channel ANKTM1. Nature 2004, 427: 260-265. PMID: 14712238, DOI: 10.1038/nature02282.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAnimals, NewbornAnkyrinsCalcium ChannelsCalcium SignalingCannabinoidsCapsaicinCarbacholCells, CulturedCloning, MolecularDronabinolHumansMustard PlantNerve Tissue ProteinsNeurons, AfferentNociceptorsOocytesPlant OilsRatsRats, Sprague-DawleyRNA, MessengerThapsigarginTransient Receptor Potential ChannelsTrigeminal GanglionTRPA1 Cation ChannelTRPC Cation ChannelsConceptsMustard oilPrimary sensory neuronsSensory nerve fibersSensory nerve endingsTRP ion channel familyExcitatory effectsNerve endingsNerve fibersIon channel familyPungent ingredientSensory neuronsTopical applicationPsychoactive componentΔ9-tetrahydrocannabinolTRP channelsMolecular targetsANKTM1Channel familyMolecular mechanismsAllyl isothiocyanatePainInflammationWidespread useCapsaicinHypersensitivity