2017
Menthol disrupts nicotine’s psychostimulant properties in an age and sex-dependent manner in C57BL/6J mice
Fait BW, Thompson DC, Mose TN, Jatlow P, Jordt SE, Picciotto MR, Mineur YS. Menthol disrupts nicotine’s psychostimulant properties in an age and sex-dependent manner in C57BL/6J mice. Behavioural Brain Research 2017, 334: 72-77. PMID: 28743602, PMCID: PMC5580257, DOI: 10.1016/j.bbr.2017.07.027.Peer-Reviewed Original ResearchConceptsAdult male miceNicotine intakeMale micePsychostimulant effectsPsychostimulant propertiesHome cage locomotor activitySex-dependent mannerSex-dependent mechanismsBlood levelsAdolescent miceFemale miceLocomotor stimulationLocomotor activityNicotine sensitivityAge groupsE-cigarettesMiceIntakeSignificant decreaseNicotineAgeSexBehavioral changesAdultsSpecific mechanisms
2010
Role of Metabolic Activation and the TRPA1 Receptor in the Sensory Irritation Response to Styrene and Naphthalene
Lanosa M, Willis D, Jordt S, Morris J. Role of Metabolic Activation and the TRPA1 Receptor in the Sensory Irritation Response to Styrene and Naphthalene. Toxicological Sciences 2010, 115: 589-595. PMID: 20176620, PMCID: PMC2948824, DOI: 10.1093/toxsci/kfq057.Peer-Reviewed Original ResearchConceptsSensory irritation responseIrritation responseTransient receptor potential ankyrin 1 receptorMetabolic activationFemale C57BL/6J miceCytochrome P450 activationTRPA1 receptorsC57BL/6J miceCYP450 metabolitesPlethysmographic measurementsPpm styreneSensory irritationInhibitor metyraponeP450 activationPpm naphthaleneReceptorsMiceActivationCurrent studyCritical roleResponseMetyraponeIrritationRole
2007
The menthol receptor TRPM8 is the principal detector of environmental cold
Bautista DM, Siemens J, Glazer JM, Tsuruda PR, Basbaum AI, Stucky CL, Jordt SE, Julius D. The menthol receptor TRPM8 is the principal detector of environmental cold. Nature 2007, 448: 204-208. PMID: 17538622, DOI: 10.1038/nature05910.Peer-Reviewed Original ResearchConceptsMenthol receptor TRPM8TRPM8 knockout miceIntact nerve fibersDifferent ion channelsNerve fibersWhole animal testsKnockout miceNoxious coldCold stimuliCold sensationCold transducerInnocuous coolEnvironmental coldTRPM8MiceIon channelsAnimal testsCellular levelPhysiological importanceCold sensitivity
2006
TRPA1 Mediates the Inflammatory Actions of Environmental Irritants and Proalgesic Agents
Bautista DM, Jordt SE, Nikai T, Tsuruda PR, Read AJ, Poblete J, Yamoah EN, Basbaum AI, Julius D. TRPA1 Mediates the Inflammatory Actions of Environmental Irritants and Proalgesic Agents. Cell 2006, 124: 1269-1282. PMID: 16564016, DOI: 10.1016/j.cell.2006.02.023.Peer-Reviewed Original ResearchConceptsTRPA1-deficient miceInflammatory painEnvironmental irritantsInflammatory actionsProalgesic agentsPrimary afferent nociceptorsExcitatory ion channelPain hypersensitivityPungent irritantsAfferent nociceptorsNociceptor excitationAuditory functionThermal nociceptionNoxious coldMice exhibitChemotherapeutic agentsTRPA1PainIrritantsNociceptorsMiceSole targetMustard oilIon channelsInitial detection