2020
Late Breaking Abstract - The airway sensory nerve transcriptome: evidence for neuropathic injury following lipopolysaccharide induced lung inflammation
Caceres A, Kaelberer M, Jordt S. Late Breaking Abstract - The airway sensory nerve transcriptome: evidence for neuropathic injury following lipopolysaccharide induced lung inflammation. 2020, 902. DOI: 10.1183/13993003.congress-2020.902.Peer-Reviewed Original ResearchTransient receptor potential channels in pulmonary chemical injuries and as countermeasure targets
Achanta S, Jordt S. Transient receptor potential channels in pulmonary chemical injuries and as countermeasure targets. Annals Of The New York Academy Of Sciences 2020, 1480: 73-103. PMID: 32892378, PMCID: PMC7933981, DOI: 10.1111/nyas.14472.Peer-Reviewed Original ResearchConceptsChemical injuryTRP channelsNeurogenic inflammatory pathwaysChemical threat agentsMediator of injuryTransient receptor potential channelsTransient receptor potential (TRP) ion channelsIntracellular calcium levelsToxic inhalation hazardPotential ion channelsCough reflexPulmonary injuryPulmonary edemaProinflammatory cellsInflammatory pathwaysPathophysiologic eventsOccupational exposureMucus clearanceCalcium levelsInjuryNonneuronal pathwaysRespiratory systemBroader indicationsPotential channelsInhalation hazard
2019
The sensory irritant receptor TRPA1 is essential for airway inflammation in the LPS mouse model of acute lung injury
Caceres A, Jordt S. The sensory irritant receptor TRPA1 is essential for airway inflammation in the LPS mouse model of acute lung injury. 2019, pa3885. DOI: 10.1183/13993003.congress-2019.pa3885.Peer-Reviewed Original ResearchTRPV4 Inhibitor Improves Pulmonary Function and Oxygen Saturation in a Pig Translational Model of Chlorine Gas-Induced Acute Lung Injury
Achanta S, Liu B, Gentile M, Caceres A, Behm D, Burgert M, Costell M, Cheifetz I, Gunn M, Jordt S. TRPV4 Inhibitor Improves Pulmonary Function and Oxygen Saturation in a Pig Translational Model of Chlorine Gas-Induced Acute Lung Injury. 2019, a1017-a1017. DOI: 10.1164/ajrccm-conference.2019.199.1_meetingabstracts.a1017.Peer-Reviewed Original Research
2016
Tear gas: an epidemiological and mechanistic reassessment
Rothenberg C, Achanta S, Svendsen ER, Jordt S. Tear gas: an epidemiological and mechanistic reassessment. Annals Of The New York Academy Of Sciences 2016, 1378: 96-107. PMID: 27391380, PMCID: PMC5096012, DOI: 10.1111/nyas.13141.Peer-Reviewed Original ResearchConceptsTear gas agentsPeripheral sensory neuronsRecent epidemiological studiesIon channel TRPV1Lung injuryChronic morbidityOcular injuriesChronic painHigh riskSensory neuronsEpidemiological studiesAnimal modelsGas injuryInjuryPromising effectsMechanistic researchTRPV1Pepper sprayTRPA1Health risksTear gasRiskCivilian populationPotential inhibitorsCough