2021
The Airway Sensory Nerve Transcriptome: Evidence for Neuropathic Injury Following Lipopolysaccharide Induced Lung Inflammation
Caceres A, Kaelberer M, Jordt S. The Airway Sensory Nerve Transcriptome: Evidence for Neuropathic Injury Following Lipopolysaccharide Induced Lung Inflammation. 2021, a1311-a1311. DOI: 10.1164/ajrccm-conference.2021.203.1_meetingabstracts.a1311.Peer-Reviewed Original Research
2020
Late Breaking Abstract - The airway sensory nerve transcriptome: evidence for neuropathic injury following lipopolysaccharide induced lung inflammation
Caceres A, Kaelberer M, Jordt S. Late Breaking Abstract - The airway sensory nerve transcriptome: evidence for neuropathic injury following lipopolysaccharide induced lung inflammation. 2020, 902. DOI: 10.1183/13993003.congress-2020.902.Peer-Reviewed Original ResearchThe Airway Sensory Nerve Transcriptome: Evidence for Neuropathic Injury Following Lipopolysaccharide Induced Lung Inflammation
Caceres A, Kaelberer M, Jordt S. The Airway Sensory Nerve Transcriptome: Evidence for Neuropathic Injury Following Lipopolysaccharide Induced Lung Inflammation. 2020, a1794-a1794. DOI: 10.1164/ajrccm-conference.2020.201.1_meetingabstracts.a1794.Peer-Reviewed Original Research
2019
The sensory irritant receptor TRPA1 is essential for airway inflammation in the LPS mouse model of acute lung injury
Caceres A, Jordt S. The sensory irritant receptor TRPA1 is essential for airway inflammation in the LPS mouse model of acute lung injury. 2019, pa3885. DOI: 10.1183/13993003.congress-2019.pa3885.Peer-Reviewed Original Research
2016
The anti-inflammatory effects of eucalyptol in a mouse model of LPS-induced pulmonary inflammation are mediated by TRPM8
de Caceres Bustos A, Liu B, Jabba S, Morris J, Jordt S. The anti-inflammatory effects of eucalyptol in a mouse model of LPS-induced pulmonary inflammation are mediated by TRPM8. 2016, oa4541. DOI: 10.1183/13993003.congress-2016.oa4541.Peer-Reviewed Original Research
2008
Breathtaking TRP Channels: TRPA1 and TRPV1 in Airway Chemosensation and Reflex Control
Bessac BF, Jordt SE. Breathtaking TRP Channels: TRPA1 and TRPV1 in Airway Chemosensation and Reflex Control. Physiology 2008, 23: 360-370. PMID: 19074743, PMCID: PMC2735846, DOI: 10.1152/physiol.00026.2008.Peer-Reviewed Original ResearchConceptsReactive airways dysfunction syndromeAirway reflex responsesAirways dysfunction syndromeAirway inflammationChronic coughDysfunction syndromeTRP ion channelsReflex responsesReflex controlCapsaicin receptorChemical hypersensitivityTRPA1Reactive oxygen speciesInflammationTRPV1Noxious constituentsIon channelsOxygen speciesNew studiesCOPDCoughAsthmaSyndromeHypersensitivityIrritation
2005
Pungent products from garlic activate the sensory ion channel TRPA1
Bautista DM, Movahed P, Hinman A, Axelsson HE, Sterner O, Högestätt ED, Julius D, Jordt SE, Zygmunt PM. Pungent products from garlic activate the sensory ion channel TRPA1. Proceedings Of The National Academy Of Sciences Of The United States Of America 2005, 102: 12248-12252. PMID: 16103371, PMCID: PMC1189336, DOI: 10.1073/pnas.0505356102.Peer-Reviewed Original ResearchConceptsSensory nerve endingsSensory neuronsNerve endingsTRPA1 channelsDiallyl disulfidePrimary sensory neuronsActivation of TRPA1Ion channel TRPA1Excitatory ion channelPain pathwaysPungent ingredientAllium familyVasorelaxant activityTRPA1Health benefitsNeuronsAllium extractsIon channelsAllicinMolecular mechanismsAllyl isothiocyanateEndingsPainVasodilationInflammation
2004
Mustard oils and cannabinoids excite sensory nerve fibres through the TRP channel ANKTM1
Jordt SE, Bautista DM, Chuang HH, McKemy DD, Zygmunt PM, Högestätt ED, Meng ID, Julius D. Mustard oils and cannabinoids excite sensory nerve fibres through the TRP channel ANKTM1. Nature 2004, 427: 260-265. PMID: 14712238, DOI: 10.1038/nature02282.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAnimals, NewbornAnkyrinsCalcium ChannelsCalcium SignalingCannabinoidsCapsaicinCarbacholCells, CulturedCloning, MolecularDronabinolHumansMustard PlantNerve Tissue ProteinsNeurons, AfferentNociceptorsOocytesPlant OilsRatsRats, Sprague-DawleyRNA, MessengerThapsigarginTransient Receptor Potential ChannelsTrigeminal GanglionTRPA1 Cation ChannelTRPC Cation ChannelsConceptsMustard oilPrimary sensory neuronsSensory nerve fibersSensory nerve endingsTRP ion channel familyExcitatory effectsNerve endingsNerve fibersIon channel familyPungent ingredientSensory neuronsTopical applicationPsychoactive componentΔ9-tetrahydrocannabinolTRP channelsMolecular targetsANKTM1Channel familyMolecular mechanismsAllyl isothiocyanatePainInflammationWidespread useCapsaicinHypersensitivity