2007
The menthol receptor TRPM8 is the principal detector of environmental cold
Bautista DM, Siemens J, Glazer JM, Tsuruda PR, Basbaum AI, Stucky CL, Jordt SE, Julius D. The menthol receptor TRPM8 is the principal detector of environmental cold. Nature 2007, 448: 204-208. PMID: 17538622, DOI: 10.1038/nature05910.Peer-Reviewed Original ResearchConceptsMenthol receptor TRPM8TRPM8 knockout miceIntact nerve fibersDifferent ion channelsNerve fibersWhole animal testsKnockout miceNoxious coldCold stimuliCold sensationCold transducerInnocuous coolEnvironmental coldTRPM8MiceIon channelsAnimal testsCellular levelPhysiological importanceCold sensitivity
2001
Bradykinin and nerve growth factor release the capsaicin receptor from PtdIns(4,5)P2-mediated inhibition
Chuang H, Prescott E, Kong H, Shields S, Jordt S, Basbaum A, Chao M, Julius D. Bradykinin and nerve growth factor release the capsaicin receptor from PtdIns(4,5)P2-mediated inhibition. Nature 2001, 411: 957-962. PMID: 11418861, DOI: 10.1038/35082088.Peer-Reviewed Original ResearchConceptsPlasma membrane phosphatidylinositolNerve growth factorTyrosine kinase receptorsActivation of PLCGrowth factorTRP channel familyMembrane phosphatidylinositolChannel familyKinase receptorsBiochemical mechanismsMolecular levelBiochemical studiesIon channelsCellular levelChannel activityHeat-activated ion channelExpression of VR1Sensory nerve endingsChemical stimuliSense of painSensory neuronsEndogenous factorsPrimary afferentsNerve endingsCapsaicin receptor