2017
Ankyrin‐rich membrane spanning protein as a novel modulator of transient receptor potential vanilloid 1‐function in nociceptive neurons
Peter J, Kasper C, Kaufholz M, Buschow R, Isensee J, Hucho T, Herberg F, Schwede F, Stein C, Jordt S, Brackmann M, Spahn V. Ankyrin‐rich membrane spanning protein as a novel modulator of transient receptor potential vanilloid 1‐function in nociceptive neurons. European Journal Of Pain 2017, 21: 1072-1086. PMID: 28182310, PMCID: PMC5504413, DOI: 10.1002/ejp.1008.Peer-Reviewed Original ResearchConceptsAnkyrin-rich membranePKA-dependent mannerKinase DHEK-293 cellsSensitivity of TRPV1Immunoprecipitation experimentsDRG neuronsNovel modulatorRodent DRG neuronsIon channelsIon channel TRPV1Excitatory ion channelSmall-diameter dorsal root ganglion neuronsTransient receptor potential vanilloidImportant componentDorsal root ganglion neuronsPeripheral sensory neuronsMouse DRG neuronsChemical stimuliSensory neuronsCellsComplexesMembraneDirect modificationTRPV1 expression
2001
Male germ cells and photoreceptors, both dependent on close cell–cell interactions, degenerate upon ClC‐2 Cl− channel disruption
Bösl M, Stein V, Hübner C, Zdebik A, Jordt S, Mukhopadhyay A, Davidoff M, Holstein A, Jentsch T. Male germ cells and photoreceptors, both dependent on close cell–cell interactions, degenerate upon ClC‐2 Cl− channel disruption. The EMBO Journal 2001, 20: 1289-1299. PMID: 11250895, PMCID: PMC145530, DOI: 10.1093/emboj/20.6.1289.Peer-Reviewed Original ResearchConceptsClC-2Abnormal Sertoli cellsBlood-retina barrierGerm cellsRetinal pigment epitheliumCl- channelsSevere degenerationMale infertilityPigment epitheliumMale germ cellsClC-2 Cl(-) channelOvert abnormalitiesSeminiferous tubulesNormal outer segmentsSertoli cellsOuter segmentsRetinaCell typesDeathMassive deathCellsPrimary spermatocytesHuman diseasesTubulesCLC Cl(-) channels