2011
Menthol attenuates respiratory irritation responses to multiple cigarette smoke irritants
Willis DN, Liu B, Ha MA, Jordt S, Morris JB. Menthol attenuates respiratory irritation responses to multiple cigarette smoke irritants. The FASEB Journal 2011, 25: 4434-4444. PMID: 21903934, PMCID: PMC3236628, DOI: 10.1096/fj.11-188383.Peer-Reviewed Original ResearchConceptsTransient receptor potential ankyrin 1Irritation responseMenthol effectsCold-sensitive sensory neuronsSensory TRP channelsSmoking-related morbiditySensory irritation responseEffect of mentholTransient receptor potential melastatin 8 (TRPM8) ion channelActivation of TRPM8TRPM8 agonistTRPM8 antagonistsCapsaicin receptorRespiratory tractSensory neuronsAnkyrin 1Pharmacological actionsNicotine addictionSmoking behaviorRespiratory irritationTRP channelsAgonistsSmoke constituentsAvailable cigarettesCigarettes
2008
Breathtaking TRP Channels: TRPA1 and TRPV1 in Airway Chemosensation and Reflex Control
Bessac BF, Jordt SE. Breathtaking TRP Channels: TRPA1 and TRPV1 in Airway Chemosensation and Reflex Control. Physiology 2008, 23: 360-370. PMID: 19074743, PMCID: PMC2735846, DOI: 10.1152/physiol.00026.2008.Peer-Reviewed Original ResearchConceptsReactive airways dysfunction syndromeAirway reflex responsesAirways dysfunction syndromeAirway inflammationChronic coughDysfunction syndromeTRP ion channelsReflex responsesReflex controlCapsaicin receptorChemical hypersensitivityTRPA1Reactive oxygen speciesInflammationTRPV1Noxious constituentsIon channelsOxygen speciesNew studiesCOPDCoughAsthmaSyndromeHypersensitivityIrritation
2003
Molecular determinants of ligand interaction with the capsaicin receptor
Jordt S, Julius D. Molecular determinants of ligand interaction with the capsaicin receptor. Journal Of Neurochemistry 2003, 85: 4-4. DOI: 10.1046/j.1471-4159.85.s2.4_3.x.Peer-Reviewed Original ResearchReceptor homologPutative transmembrane regionsTransmembrane regionChemical modification studiesChimeric analysisPlasma membraneReceptor orthologsTransmembrane moietyStructural domainsMolecular determinantsChemical labelingIntracellular sideLigand binding assaysStructural determinantsLigand interactionsHomologPain-producing effectsBinding assaysModification studiesEndogenous ligandCapsaicin receptorReceptorsOrthologsMutagenesisBirds
2001
Bradykinin and nerve growth factor release the capsaicin receptor from PtdIns(4,5)P2-mediated inhibition
Chuang H, Prescott E, Kong H, Shields S, Jordt S, Basbaum A, Chao M, Julius D. Bradykinin and nerve growth factor release the capsaicin receptor from PtdIns(4,5)P2-mediated inhibition. Nature 2001, 411: 957-962. PMID: 11418861, DOI: 10.1038/35082088.Peer-Reviewed Original ResearchConceptsPlasma membrane phosphatidylinositolNerve growth factorTyrosine kinase receptorsActivation of PLCGrowth factorTRP channel familyMembrane phosphatidylinositolChannel familyKinase receptorsBiochemical mechanismsMolecular levelBiochemical studiesIon channelsCellular levelChannel activityHeat-activated ion channelExpression of VR1Sensory nerve endingsChemical stimuliSense of painSensory neuronsEndogenous factorsPrimary afferentsNerve endingsCapsaicin receptor