2023
The KDM6A-KMT2D-p300 axis regulates susceptibility to diverse coronaviruses by mediating viral receptor expression
Wei J, Alfajaro M, Cai W, Graziano V, Strine M, Filler R, Biering S, Sarnik S, Patel S, Menasche B, Compton S, Konermann S, Hsu P, Orchard R, Yan Q, Wilen C. The KDM6A-KMT2D-p300 axis regulates susceptibility to diverse coronaviruses by mediating viral receptor expression. PLOS Pathogens 2023, 19: e1011351. PMID: 37410700, PMCID: PMC10325096, DOI: 10.1371/journal.ppat.1011351.Peer-Reviewed Original ResearchConceptsMouse hepatitis virusReceptor expressionTherapeutic targetMERS-CoVMajor SARS-CoV-2 variantsPrimary human airwaySARS-CoV-2 variantsNovel therapeutic targetViral receptor expressionSARS-CoV-2Histone methyltransferase KMT2DIntestinal epithelial cellsCoronavirus SusceptibilityDiverse coronavirusesHistone demethylase KDM6ADPP4 expressionCoronavirus receptorsHost determinantsHepatitis virusHuman airwaysSARS-CoVSmall molecule inhibitionViral entryPotential drug targetsViral receptors
2015
Effect of Cage-Wash Temperature on the Removal of Infectious Agents from Caging and the Detection of Infectious Agents on the Filters of Animal Bedding-Disposal Cabinets by PCR Analysis.
Compton SR, Macy JD. Effect of Cage-Wash Temperature on the Removal of Infectious Agents from Caging and the Detection of Infectious Agents on the Filters of Animal Bedding-Disposal Cabinets by PCR Analysis. Journal Of The American Association For Laboratory Animal Science 2015, 54: 745-55. PMID: 26632784, PMCID: PMC4671790.Peer-Reviewed Original ResearchConceptsMouse hepatitis virusMouse parvovirusMyocoptes musculinusInfectious agentsS. obvelataDetection of infectionHepatitis virusPCR analysisHousing micePathogen transmissionFacility levelMiceCages housing miceHelicobacter sppM. pulmonisSyphacia obvelataMycoplasma pulmonisCage washingParvovirusAnimal facilitiesSentinelsVirusAgentsPulmonisPathogen screening
1996
Growth characteristics and protein profiles of prototype and wild-type rat coronavirus isolates grown in a cloned subline of mouse fibroblasts (L2p.176 cells)
Gaertner D, Compton S, Winograd D, Smith A. Growth characteristics and protein profiles of prototype and wild-type rat coronavirus isolates grown in a cloned subline of mouse fibroblasts (L2p.176 cells). Virus Research 1996, 41: 55-68. PMID: 8725102, PMCID: PMC7134090, DOI: 10.1016/0168-1702(95)01274-5.Peer-Reviewed Original ResearchConceptsMouse hepatitis virus
1994
Enterotropic Strains of Mouse Coronavirus Differ in Their Use of Murine Carcinoembryonic Antigen-Related Glycoprotein Receptors
Compton S. Enterotropic Strains of Mouse Coronavirus Differ in Their Use of Murine Carcinoembryonic Antigen-Related Glycoprotein Receptors. Virology 1994, 203: 197-201. PMID: 8030279, PMCID: PMC7131022, DOI: 10.1006/viro.1994.1475.Peer-Reviewed Original ResearchConceptsSJL miceLimited tissue tropismMHV-RIEnterotropic mouse hepatitis virusBALB/c miceTissue tropismMonoclonal antibody CC1BALB/cMouse hepatitis virusRole of receptorsMurine carcinoembryonic antigenC miceEnterotropic strainsHepatitis virusCarcinoembryonic antigenBHK cellsInfectionMiceDifferent receptorsReceptorsCell linesGlycoprotein receptorsMurine tissuesMouse coronavirusMHV
1990
Is the 110K Glycoprotein the Only Receptor for MHV and Does Its Expression Determine Species Specificity?
Holmes K, Williams R, Cardellichio C, Compton S, Stephensen C, Snyder S, Frana M, Jiang G, Smith A, Knobler R. Is the 110K Glycoprotein the Only Receptor for MHV and Does Its Expression Determine Species Specificity? Advances In Experimental Medicine And Biology 1990, 276: 37-44. PMID: 1966425, DOI: 10.1007/978-1-4684-5823-7_6.Peer-Reviewed Original ResearchConceptsSJL/J miceNormal target tissuesJ miceMHV-A59BALB/c miceTarget tissuesVirus overlay protein blot assaySJL/JMouse hepatitis virusSusceptible miceBinding of virionsC miceHepatitis virusOnly receptorBlot assaysVirus bindingMiceTissue tropismIntestine membranesMurine virusesHepatocyte membraneProtein blot assayVirusInfectionMolecular mechanisms