Featured Publications
Ketogenic diet enhances the effects of oxycodone in mice
Trinko R, Diaz D, Foscue E, Thompson S, Taylor J, DiLeone R. Ketogenic diet enhances the effects of oxycodone in mice. Scientific Reports 2023, 13: 7507. PMID: 37160959, PMCID: PMC10170077, DOI: 10.1038/s41598-023-33458-8.Peer-Reviewed Original ResearchConceptsOpioid use disorderKetogenic dietKD miceUse disordersTreatment of OUDEffects of KDEffects of oxycodoneClinical pain managementAlcohol use disorderProgressive ratio scheduleSex-specific effectsChronic oxycodoneLess oxycodoneOpioid withdrawalAntinociceptive effectPain managementPrescription opioidsSide effectsOxycodoneLocomotor activityTherapeutic potentialOpioidsDietary effectsOpiate sensitivityMiceMPEP Lowers Binge Drinking in Male and Female C57BL/6 Mice: Relationship with mGlu5/Homer2/Erk2 Signaling
Huang G, Thompson SL, Taylor JR. MPEP Lowers Binge Drinking in Male and Female C57BL/6 Mice: Relationship with mGlu5/Homer2/Erk2 Signaling. Alcohol Clinical And Experimental Research 2021, 45: 732-742. PMID: 33587295, PMCID: PMC8076072, DOI: 10.1111/acer.14576.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBinge DrinkingDose-Response Relationship, DrugDrug Evaluation, PreclinicalExcitatory Amino Acid AntagonistsFemaleHomer Scaffolding ProteinsMaleMAP Kinase Signaling SystemMice, Inbred C57BLMitogen-Activated Protein Kinase 1Nucleus AccumbensPyridinesReceptor, Metabotropic Glutamate 5Septal NucleiSex CharacteristicsConceptsEffects of MPEPFemale C57BL/6 miceAlcohol intakeAlcohol consumptionNegative allosteric modulatorsLocomotor activityC57BL/6 miceFemale miceMale miceHomer2 expressionBinge drinkingMetabotropic glutamate receptor 5MGlu5 negative allosteric modulatorsSex differencesBinge alcohol consumptionGlutamate receptor 5Dose-response effectExcessive alcohol useERK2 expressionDose-response relationshipPotential sex differencesERK2 signalingBed nucleusNucleus accumbensStria terminalis
2023
Mice lacking Ptprd exhibit deficits in goal-directed behavior and female-specific impairments in sensorimotor gating
Ho E, Welch A, Thompson S, Knowles J, Dulawa S. Mice lacking Ptprd exhibit deficits in goal-directed behavior and female-specific impairments in sensorimotor gating. PLOS ONE 2023, 18: e0277446. PMID: 37205689, PMCID: PMC10198499, DOI: 10.1371/journal.pone.0277446.Peer-Reviewed Original ResearchConceptsProtein tyrosine phosphatase receptor type DGenome-wide association studiesProtein tyrosine phosphatase familyTyrosine phosphatase familyReceptor type DPhosphatase familyAssociation studiesGenetic studiesCell adhesionPTPRDNest-building behaviorEffect of genotypeSynaptic specificationNeuropsychiatric phenotypesTraitsConstitutive lackKnockout miceKO miceGatingLociBuilding behaviorMicePhenotype
2018
Dlgap1 knockout mice exhibit alterations of the postsynaptic density and selective reductions in sociability
Coba MP, Ramaker MJ, Ho EV, Thompson SL, Komiyama NH, Grant SGN, Knowles JA, Dulawa SC. Dlgap1 knockout mice exhibit alterations of the postsynaptic density and selective reductions in sociability. Scientific Reports 2018, 8: 2281. PMID: 29396406, PMCID: PMC5797244, DOI: 10.1038/s41598-018-20610-y.Peer-Reviewed Original Research
2009
Cone photoreceptor mosaic disruption associated with Cys203Arg mutation in the M-cone opsin
Carroll J, Baraas RC, Wagner-Schuman M, Rha J, Siebe CA, Sloan C, Tait DM, Thompson S, Morgan JI, Neitz J, Williams DR, Foster DH, Neitz M. Cone photoreceptor mosaic disruption associated with Cys203Arg mutation in the M-cone opsin. Proceedings Of The National Academy Of Sciences Of The United States Of America 2009, 106: 20948-20953. PMID: 19934058, PMCID: PMC2791574, DOI: 10.1073/pnas.0910128106.Peer-Reviewed Original ResearchConceptsEarly-onset retinitis pigmentosaOuter nuclear layerM-cone opsinCone opsin mutationsColor vision defectsVision lossCommon causeNuclear layerCone functionRetinitis pigmentosaCone densityVision defectsMosaic disruptionSubstitution of arginineFrequent mutationsColor vision deficiencyCone opsinsGreen color vision defectsSignificant reduction