Featured Publications
Lesions to the mediodorsal thalamus, but not orbitofrontal cortex, enhance volatility beliefs linked to paranoia
Suthaharan P, Thompson S, Rossi-Goldthorpe R, Rudebeck P, Walton M, Chakraborty S, Noonan M, Costa V, Murray E, Mathys C, Groman S, Mitchell A, Taylor J, Corlett P, Chang S. Lesions to the mediodorsal thalamus, but not orbitofrontal cortex, enhance volatility beliefs linked to paranoia. Cell Reports 2024, 43: 114355. PMID: 38870010, PMCID: PMC11231991, DOI: 10.1016/j.celrep.2024.114355.Peer-Reviewed Original ResearchOrbitofrontal cortexMediodorsal thalamusReward learning rateAssociated with paranoiaExcitotoxic lesionsBrain regionsUnoperated monkeysAction selectionAdaptive behaviorParanoiaBelief updatingMDmcMeaningful changeCortexThalamusBeliefsLearning rateRobust to variabilityCompare performanceRewardBehaviorBrainMonkeysAction policiesPerception
2015
Clinically effective OCD treatment prevents 5-HT1B receptor-induced repetitive behavior and striatal activation
Ho EV, Thompson SL, Katzka WR, Sharifi MF, Knowles JA, Dulawa SC. Clinically effective OCD treatment prevents 5-HT1B receptor-induced repetitive behavior and striatal activation. Psychopharmacology 2015, 233: 57-70. PMID: 26423528, DOI: 10.1007/s00213-015-4086-8.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCorpus StriatumDesipramineExploratory BehaviorFemaleFluoxetineIndolesMiceMice, Inbred C57BLObsessive-Compulsive DisorderReceptor, Serotonin, 5-HT1BSerotonin 5-HT1 Receptor AgonistsSerotonin 5-HT1 Receptor AntagonistsSerotonin Receptor AgonistsStereotyped BehaviorTreatment OutcomeConceptsAcute treatmentFos expressionDorsal striatumOCD treatmentStriatal activationReceptor agonist treatmentEffective OCD treatmentOpen-field behaviorChronic fluoxetineAgonist treatmentObsessive-compulsive disorderChronic pretreatmentLocomotor stereotypySeparate miceNeuronal activationDrug treatmentTreatment preventsRepetitive behaviorsOCD pathophysiologyBrain regionsOrbitofrontal cortexBehavioral effectsRU24969Inhibition deficitsBrain activation