Neuroprotective potential of quercetin in combination with piperine against 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced neurotoxicity
Singh S, Jamwal S, Kumar P. Neuroprotective potential of quercetin in combination with piperine against 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced neurotoxicity. Neural Regeneration Research 2017, 12: 1137-1144. PMID: 28852397, PMCID: PMC5558494, DOI: 10.4103/1673-5374.211194.Peer-Reviewed Original ResearchSubstantia nigra pars compactaAnti-inflammatory propertiesPars compactaNeuroprotective potentialTetrahydropyridine-induced neurotoxicityInjection of MPTPStrong neuroprotective effectSignificant motor deficitsBioavailability of antioxidantsOpen field testOxidative stress parametersLow oral bioavailabilityNeuroinflammatory cytokinesMotor deficitsNeuroprotective effectsRotarod performanceCombination therapyDopaminergic neuronsGrip strengthInflammatory responseBilateral infusionsBehavioral abnormalitiesDay 1MPTPStereotaxic apparatus