2015
Beneficial effect of zinc chloride and zinc ionophore pyrithione on attenuated cardioprotective potential of preconditioning phenomenon in STZ-induced diabetic rat heart
Jamwal S, Kumar K, Reddy BV. Beneficial effect of zinc chloride and zinc ionophore pyrithione on attenuated cardioprotective potential of preconditioning phenomenon in STZ-induced diabetic rat heart. Perfusion 2015, 31: 334-342. PMID: 26423303, DOI: 10.1177/0267659115608935.Peer-Reviewed Original ResearchConceptsDiabetic rat heartsMyocardial infarct sizeCreatine kinase-MBZinc ionophore pyrithioneIschemic preconditioningNormal rat heartsCardioprotective potentialInfarct sizeRat heartMPO levelsDiabetes mellitusCoronary effluentLactate dehydrogenaseSTZ-induced diabetic rat heartIonophore pyrithioneGSK-3βPost-ischemic treatmentMinutes of reperfusionRelease of LDHMinutes of ischemiaTriphenyltetrazolium chloride stainingGSK-3β levelsSingle intraperitoneal administrationGlycogen synthase kinase-3βNeutrophil accumulation
2014
Mechanisms involved in attenuated cardio-protective role of ischemic preconditioning in metabolic disorders
Rana A, Goyal N, Ahlawat A, Jamwal S, Reddy B, Sharma S. Mechanisms involved in attenuated cardio-protective role of ischemic preconditioning in metabolic disorders. Perfusion 2014, 30: 94-105. PMID: 24947460, DOI: 10.1177/0267659114536760.Peer-Reviewed Original ResearchConceptsCalcitonin gene-related peptideIschemic preconditioningDiabetes mellitusMito-KATP channelMitochondrial permeability transition poreChronic diabetes mellitusGene-related peptideCardio-protective roleIschemia/reperfusionSub-lethal ischemiaGlycogen synthase kinase-3βSynthase kinase-3βCardioprotective effectsMyocardial damageMyocardial infarctionBlood supplyPart of heartMetabolic disordersInvolvement of PTENBeneficial effectsPTEN inhibitorKinase-3βPathological statesMellitusHyperlipidemia