2012
An AnkyrinG-Binding Motif Is Necessary and Sufficient for Targeting Nav1.6 Sodium Channels to Axon Initial Segments and Nodes of Ranvier
Gasser A, Ho TS, Cheng X, Chang KJ, Waxman SG, Rasband MN, Dib-Hajj SD. An AnkyrinG-Binding Motif Is Necessary and Sufficient for Targeting Nav1.6 Sodium Channels to Axon Initial Segments and Nodes of Ranvier. Journal Of Neuroscience 2012, 32: 7232-7243. PMID: 22623668, PMCID: PMC3413458, DOI: 10.1523/jneurosci.5434-11.2012.Peer-Reviewed Original ResearchConceptsReporter proteinAxon initial segmentKinase phosphorylation siteSodium channelsIntracellular loop 2Nodes of RanvierFull-length channelGlutamic acid residuesPhosphorylation sitesMechanism of channelVoltage-gated sodium channelsAcid residuesLoop 2Functional mouseNav1.6 sodium channelsMotifProteinVivo analysisAnkyrinGSomatodendritic compartmentCultured neuronsInitial segmentVivoAction potentialsCells
1997
Schwann cells modulate sodium channel expression in spinal sensory neurons in vitro
Hinson AW, Gu XQ, Dib‐Hajj S, Black JA, Waxman SG. Schwann cells modulate sodium channel expression in spinal sensory neurons in vitro. Glia 1997, 21: 339-349. PMID: 9419009, DOI: 10.1002/(sici)1098-1136(199712)21:4<339::aid-glia1>3.0.co;2-z.Peer-Reviewed Original ResearchConceptsDRG neuronsSC-conditioned mediumSodium channel alphaE15 ratsSodium channelsChannel alphaSodium channel immunoreactivitySpinal sensory neuronsBeta2 subunit mRNASodium channel mRNASodium channel expressionFunctional sodium channelsSodium current densityBeta-subunit mRNAChannel immunoreactivityBeta2 mRNASensory neuronsClamp recordingsChannel expressionChannel mRNAIsoform-specific riboprobesNeuronsBeta1RatsHybridization signals