2008
Inhibitory Effect of Tributyltin on Expression of Steroidogenic Enzymes in Mouse Testis
Kim S, Kim J, Han J, Yoon Y. Inhibitory Effect of Tributyltin on Expression of Steroidogenic Enzymes in Mouse Testis. International Journal Of Toxicology 2008, 27: 175-182. PMID: 18404541, DOI: 10.1080/10915810801977906.Peer-Reviewed Original ResearchConceptsInterstitial Leydig cellsSteroidogenic enzymesLeydig cellsImmature male miceSerum testosterone concentrationsTesticular developmentInhibition of steroidogenesisCholesterol side-chain cleavage enzymeSide-chain cleavage enzymeSteroid hormone productionGerm cellsTesticular germ cellsApoptotic germ cellsOral gavageMale miceSingle administrationTestosterone concentrationsHormone productionInhibitory effectSeminiferous tubulesAdverse effectsInduced apoptosisTBT exposureAcute toxicityCleavage enzyme
2004
PREPUBERTAL EXPOSURE TO 4-TERT-OCTYLPHENOL INDUCES APOPTOSIS OF TESTICULAR GERM CELLS IN ADULT RAT
KIM S, LEE H, YANG H, KIM H, YOON Y. PREPUBERTAL EXPOSURE TO 4-TERT-OCTYLPHENOL INDUCES APOPTOSIS OF TESTICULAR GERM CELLS IN ADULT RAT. Systems Biology In Reproductive Medicine 2004, 50: 427-441. PMID: 15669608, DOI: 10.1080/01485010490475093.Peer-Reviewed Original ResearchConceptsTesticular germ cellsEstradiol valerateSerum LH concentrationsSerum testosterone concentrationsGerm cellsWeek old ratsPrepubertal male ratsLH concentrationsMale reproductive organsMale ratsTestosterone concentrationsAdult ratsOld ratsChronic exposureMarked reductionSeminiferous tubulesRatsSeminal vesiclesBcl-2Decreased biosynthesisBax mRNAThree timesTesticular developmentBcl-xL mRNAApoptosis