2015
Pancreatic Islet-Like Three-Dimensional Aggregates Derived From Human Embryonic Stem Cells Ameliorate Hyperglycemia in Streptozotocin-Induced Diabetic Mice
Shim J, Kim J, Han J, An S, Jang Y, Son J, Woo D, Kim S, Kim J. Pancreatic Islet-Like Three-Dimensional Aggregates Derived From Human Embryonic Stem Cells Ameliorate Hyperglycemia in Streptozotocin-Induced Diabetic Mice. Cell Transplantation 2015, 24: 2155-2168. PMID: 25397866, DOI: 10.3727/096368914x685438.Peer-Reviewed Original ResearchConceptsDiabetic miceHuman embryonic stem cellsClinical islet transplantationBlood glucose levelsMature pancreatic endocrine cellsPancreatic endocrine cellsStem cellsInhibition of NotchAmeliorate hyperglycemiaIslet transplantationPancreatic hormonesGlucose levelsPancreatic endodermDonor isletsPancreatic featuresActivin APharmacological drugsEndocrine cellsIncreased expressionThree-dimensional aggregatesExpression of Neurog3Transient upregulationProgenitor cellsRetinoic acidActivin βB
2012
Sox2 Acts through Sox21 to Regulate Transcription in Pluripotent and Differentiated Cells
Kuzmichev A, Kim S, D’Alessio A, Chenoweth J, Wittko I, Campanati L, McKay R. Sox2 Acts through Sox21 to Regulate Transcription in Pluripotent and Differentiated Cells. Current Biology 2012, 22: 1705-1710. PMID: 22902753, DOI: 10.1016/j.cub.2012.07.013.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCDX2 Transcription FactorCell DifferentiationCell LineColonic NeoplasmsFibroblastsGene Expression RegulationHomeodomain ProteinsIntestinal MucosaIntestinesMiceMice, TransgenicOctamer Transcription Factor-3Pluripotent Stem CellsSOXB1 Transcription FactorsSOXB2 Transcription FactorsTranscription FactorsTranscription, GeneticTranscriptional ActivationConceptsStem cellsImportant transcriptional regulatorStem cell renewalIntestinal stem cellsAdult stem cellsColon cancer cellsEndodermal identityPluripotent stem cellsEffect of SOX2Gene familyCell identityPluripotent stateTranscriptional partnersTranscriptional regulatorsTranscriptional inductionTranscription factorsMaster regulatorTranscriptional actionGene expressionSox21Differentiated cellsCell renewalSOX2General mediatorCell types
2009
Differential cytotoxic effects of mono-(2-ethylhexyl) phthalate on blastomere-derived embryonic stem cells and differentiating neurons
Lim C, Kim S, Ko D, Cho J, Jun J, An S, Han J, Kim J, Yoon Y. Differential cytotoxic effects of mono-(2-ethylhexyl) phthalate on blastomere-derived embryonic stem cells and differentiating neurons. Toxicology 2009, 264: 145-154. PMID: 19720108, DOI: 10.1016/j.tox.2009.08.015.Peer-Reviewed Original ResearchDNA-Enrichment Microfluidic Chip for Chromatin Immunoprecipitation
Oh H, Park J, Park S, Lee B, Park J, Kim S, Yoon T, Lee S. DNA-Enrichment Microfluidic Chip for Chromatin Immunoprecipitation. Analytical Chemistry 2009, 81: 2832-2839. PMID: 19298056, DOI: 10.1021/ac802034s.Peer-Reviewed Original ResearchVitronectin promotes oligodendrocyte differentiation during neurogenesis of human embryonic stem cells
Gil J, Woo D, Shim J, Kim S, You H, Park S, Paek S, Kim S, Kim J. Vitronectin promotes oligodendrocyte differentiation during neurogenesis of human embryonic stem cells. FEBS Letters 2009, 583: 561-567. PMID: 19162023, DOI: 10.1016/j.febslet.2008.12.061.Peer-Reviewed Original Research
2007
Comparative Analysis of the Developmental Competence of Three Human Embryonic Stem Cell Lines in Vitro
Kim S, Kim B, Gil J, Kim S, Kim J. Comparative Analysis of the Developmental Competence of Three Human Embryonic Stem Cell Lines in Vitro. Molecules And Cells 2007, 23: 49-56. PMID: 17464211, DOI: 10.1016/s1016-8478(23)07388-0.Peer-Reviewed Original ResearchConceptsHuman embryonic stem cellsHESC linesHuman embryonic stem cell linesEmbryonic stem cell linesPrimordial germ cellsDevelopmental potentialEmbryonic stem cellsEmbryonic germ layersEmbryoid body formationSpecific cell typesDevelopmental competenceStem cell linesCell replacement therapyExtraembryonic tissuesStem cell technologyGerm layersTerminal differentiationGerm cellsBody formationPluripotency markersCell typesNeuronal cellsTelomerase activityStem cellsHSF6
2006
Nonylphenol and Octylphenol-Induced Apoptosis in Human Embryonic Stem Cells Is Related to Fas-Fas Ligand Pathway
Kim S, Kim B, Shim J, Gil J, Yoon Y, Kim J. Nonylphenol and Octylphenol-Induced Apoptosis in Human Embryonic Stem Cells Is Related to Fas-Fas Ligand Pathway. Toxicological Sciences 2006, 94: 310-321. PMID: 16984955, DOI: 10.1093/toxsci/kfl114.Peer-Reviewed Original ResearchConceptsHuman embryonic stem cellsUndifferentiated hES cellsEmbryonic stem cellsHES cellsNeural progenitor cellsEarly embryonic developmentStem cellsProgenitor cellsToxic stress responseChemical-induced apoptosisFas ligand protein expressionFas-Fas ligand pathwayCell replacement therapyEmbryonic developmentCaspase activationES cellsCaspase-8Stress responseDevelopmental stagesDNA fragmentationCell typesFas-FasL interactionCommon environmental contaminantsApoptosisProtein expression