Direct Functional Interactions between Insulin-like Growth Factor-binding Protein-3 and Retinoid X Receptor-α Regulate Transcriptional Signaling and Apoptosis*
Liu B, Lee H, Weinzimer S, Powell D, Clifford J, Kurie J, Cohen P. Direct Functional Interactions between Insulin-like Growth Factor-binding Protein-3 and Retinoid X Receptor-α Regulate Transcriptional Signaling and Apoptosis*. Journal Of Biological Chemistry 2000, 275: 33607-33613. PMID: 10874028, DOI: 10.1074/jbc.m002547200.Peer-Reviewed Original ResearchConceptsIGFBP-3Insulin-like growth factor-binding protein-3IGFBP-3-induced apoptosisInsulin-like growth factor-binding proteinsGrowth factor-binding proteinsRXR response elementsNuclear receptor retinoid X receptorFactor-binding proteinProstate cancer cellsReceptor retinoid X receptorRetinoid X receptorX receptorProtein 3Direct functional interactionCancer cellsRXR ligandsTranscriptional signalingApoptosisResponse elementTranscriptional activityFunctional interactionSignalingKnockout cellsCellsReceptors