2007
Genetic randomization reveals functional relationships among morphologic and tissue-quality traits that contribute to bone strength and fragility
Jepsen KJ, Hu B, Tommasini SM, Courtland HW, Price C, Terranova CJ, Nadeau JH. Genetic randomization reveals functional relationships among morphologic and tissue-quality traits that contribute to bone strength and fragility. Mammalian Genome 2007, 18: 492-507. PMID: 17557179, PMCID: PMC1998883, DOI: 10.1007/s00335-007-9017-5.Peer-Reviewed Original ResearchConceptsFunctional interactionMean trait valuesRI strainsCombination of traitsTrait valuesGenomic regionsCellular processesLoss of functionBone slendernessGenetic variabilityEnvironmental perturbationsSkeletal traitsAXB/BXAImportant functional interactionTraitsBiological paradigmBone traitsFunctional relationshipMouse strainsGenetic randomizationAdult malesHigher mineral densityStrainsUnique setGrowth
2005
Genetic Variation in Structure‐Function Relationships for the Inbred Mouse Lumbar Vertebral Body*
Tommasini SM, Morgan TG, van der Meulen MCh, Jepsen KJ. Genetic Variation in Structure‐Function Relationships for the Inbred Mouse Lumbar Vertebral Body*. Journal Of Bone And Mineral Research 2005, 20: 817-827. PMID: 15824855, DOI: 10.1359/jbmr.041234.Peer-Reviewed Original ResearchMeSH KeywordsAnalysis of VarianceAnimalsBiomechanical PhenomenaBone and BonesFemaleGenetic VariationLumbar VertebraeMiceMice, Inbred C3HMice, Inbred C57BLMice, Inbred StrainsModels, AnatomicModels, BiologicalModels, GeneticMultivariate AnalysisPhenotypeSpecies SpecificityStress, MechanicalStructure-Activity RelationshipTensile StrengthTomography, X-Ray ComputedConceptsMechanical propertiesBone mechanical propertiesTrabecular bone tissueWhole bone mechanical propertiesMeasure of ductilityTotal deformationFailure loadVertebral mechanical propertiesBone tissueIsotropic voxel sizeBiomechanical analysisImaging systemPropertiesDuctilityStructure-function relationshipsVoxel sizeDeformationBV/TVStiffness