2014
Oxygen and seizure dynamics: II. Computational modeling
Wei Y, Ullah G, Ingram J, Schiff S. Oxygen and seizure dynamics: II. Computational modeling. Journal Of Neurophysiology 2014, 112: 213-223. PMID: 24671540, PMCID: PMC4064403, DOI: 10.1152/jn.00541.2013.Peer-Reviewed Original ResearchConceptsSeizure eventsTissue oxygen pressureIntense neuronal firingSeizure patternsInhibitory neuronsNeuronal firingEpileptic seizuresSeizuresElectrophysiological recordingsOxygen metabolismSeizure dynamicsMetabolic energy consumptionEnergy metabolismExcitatoryMicroenvironment dynamicsRecent studiesOxygen and seizure dynamics: I. Experiments
Ingram J, Zhang C, Cressman J, Hazra A, Wei Y, Koo Y, Žiburkus J, Kopelman R, Xu J, Schiff S. Oxygen and seizure dynamics: I. Experiments. Journal Of Neurophysiology 2014, 112: 205-212. PMID: 24598521, PMCID: PMC4064411, DOI: 10.1152/jn.00540.2013.Peer-Reviewed Original ResearchConceptsEpileptiform activityRat hippocampal slicesLayer-specific patternsSeizure-like eventsSeizure-like stateSpontaneous seizure-like eventsHippocampal slicesSeizure onsetNeuronal interplayCellular excitabilitySeizure dynamicsEndogenous hypoxiaGreater reductionO2 utilizationHypoxiaElectrical recordingsSeizuresCA1ExcitabilityPyramidaleRapid Eye Movement Sleep and Hippocampal Theta Oscillations Precede Seizure Onset in the Tetanus Toxin Model of Temporal Lobe Epilepsy
Sedigh-Sarvestani M, Thuku G, Sunderam S, Parkar A, Weinstein S, Schiff S, Gluckman B. Rapid Eye Movement Sleep and Hippocampal Theta Oscillations Precede Seizure Onset in the Tetanus Toxin Model of Temporal Lobe Epilepsy. Journal Of Neuroscience 2014, 34: 1105-1114. PMID: 24453303, PMCID: PMC3898281, DOI: 10.1523/jneurosci.3103-13.2014.Peer-Reviewed Original ResearchConceptsRapid eye movement (REM) sleepNonrapid eye movement sleepEye movement sleepHippocampal theta rhythmState of vigilanceTemporal lobe epilepsyMovement sleepSeizure onsetLobe epilepsySeizure susceptibilityTheta rhythmChronic spontaneous seizuresNatural behavioral statesTetanus toxin modelHalf of baselineSpontaneous seizuresSeizure rateVentral hippocampusToxin modelSeizuresSurvival analysisTetanus toxinTherapeutic potentialREM boutsProminent theta
2013
Frequency dependence of behavioral modulation by hippocampal electrical stimulation
La Corte G, Wei Y, Chernyy N, Gluckman B, Schiff S. Frequency dependence of behavioral modulation by hippocampal electrical stimulation. Journal Of Neurophysiology 2013, 111: 470-480. PMID: 24198322, PMCID: PMC3921403, DOI: 10.1152/jn.00523.2013.Peer-Reviewed Original ResearchFRET excited ratiometric oxygen sensing in living tissue
Ingram J, Zhang C, Xu J, Schiff S. FRET excited ratiometric oxygen sensing in living tissue. Journal Of Neuroscience Methods 2013, 214: 45-51. PMID: 23333398, PMCID: PMC3664065, DOI: 10.1016/j.jneumeth.2013.01.002.Peer-Reviewed Original ResearchMeSH Keywords4-AminopyridineAnimalsColoring AgentsComputer SystemsConvulsantsFluorescence Resonance Energy TransferGlassHippocampusIn Vitro TechniquesLuminescent MeasurementsMetal NanoparticlesMicroelectrodesOrganoplatinum CompoundsOximetryOxygen ConsumptionPorphyrinsPyramidal CellsQuantum DotsRatsRats, Sprague-DawleySingle-Cell AnalysisConceptsInterstitial oxygen concentrationGlass substratesPolymer matrixBiocompatible sensorsInert polymer matrixDynamic analysisOptical sensorsMatrix consistingTemporal resolutionSensorsMillisecond temporal resolutionOxygen concentrationQuantum dotsMatrixRatiometric oxygenFluorescence resonance energy transferEnergy transfer
2012
Seizures as imbalanced up states: excitatory and inhibitory conductances during seizure-like events
Žiburkus J, Cressman J, Schiff S. Seizures as imbalanced up states: excitatory and inhibitory conductances during seizure-like events. Journal Of Neurophysiology 2012, 109: 1296-1306. PMID: 23221405, PMCID: PMC3602838, DOI: 10.1152/jn.00232.2012.Peer-Reviewed Original ResearchConceptsSeizure-like eventsO-LM cellsPyramidal cellsInhibitory conductanceOriens-lacunosum moleculare (O-LM) interneuronsNeuronal network hyperexcitabilityExcitability of interneuronsCA1 pyramidal cellsInhibitory synaptic conductancesNetwork hyperexcitabilityRecurrent seizuresMoleculare interneuronsSeizure initiationNeural network activityRat hippocampusExtracellular magnesiumSynaptic barragesFiring patternsSeizuresExcitatoryCellular subtypesSynaptic conductancesInterneuronsNetwork activityCell typesReconstructing Mammalian Sleep Dynamics with Data Assimilation
Sedigh-Sarvestani M, Schiff S, Gluckman B. Reconstructing Mammalian Sleep Dynamics with Data Assimilation. PLOS Computational Biology 2012, 8: e1002788. PMID: 23209396, PMCID: PMC3510073, DOI: 10.1371/journal.pcbi.1002788.Peer-Reviewed Original ResearchConceptsUnscented Kalman filterData assimilationData assimilation frameworkParameter estimation methodNonlinear computational modelSleep-wake regulatory networkAssimilation frameworkUnknown parametersHidden variablesCovariance inflationNoisy variablesSlow dynamicsSparse measurementsComputational modelModel parametersKalman filterModel statesEstimation methodSimulation studyComplex systemsOptimal variablesFilter modelUKF frameworkModel variablesPartial observabilityModulation of hippocampal rhythms by subthreshold electric fields and network topology
Berzhanskaya J, Chernyy N, Gluckman B, Schiff S, Ascoli G. Modulation of hippocampal rhythms by subthreshold electric fields and network topology. Journal Of Computational Neuroscience 2012, 34: 369-389. PMID: 23053863, PMCID: PMC3549326, DOI: 10.1007/s10827-012-0426-4.Peer-Reviewed Original ResearchConceptsPyramidal cellsGamma rhythmsHippocampal rhythmsSubthreshold electric fieldsSpecific synaptic connectivityExact cellular mechanismsExcitatory contactsSynaptic circuitryBasket cellsLines of resultsArea CA1Inhibitory connectivityInterneuron typesSynaptic connectivityInterneuron classesHippocampal functionNeuron typesNeuronal morphologyTheta/gamma ratioCognitive functionTheta frequencyCellular mechanismsNeural activityElectrophysiological dataNovel roleThe role of inhibition in oscillatory wave dynamics in the cortex
Xiao Y, Huang X, Van Wert S, Barreto E, Wu J, Gluckman B, Schiff S. The role of inhibition in oscillatory wave dynamics in the cortex. European Journal Of Neuroscience 2012, 36: 2201-2212. PMID: 22805065, PMCID: PMC4410882, DOI: 10.1111/j.1460-9568.2012.08132.x.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBicucullineCarbacholEpilepsies, PartialGABA-A Receptor AgonistsGABA-A Receptor AntagonistsGABA-B Receptor AgonistsGABA-B Receptor AntagonistsMaleMembrane PotentialsModels, NeurologicalNeocortexNeural InhibitionPicrotoxinRatsRats, Sprague-DawleyReceptors, AMPAReceptors, GABA-AReceptors, GABA-BReceptors, N-Methyl-D-AspartateTheta RhythmConceptsGABAergic inhibitionNeocortical brain slicesVoltage-sensitive dye imagingSprague-Dawley ratsPresence of carbacholConcentration-dependent mannerGABAB antagonistGABAA receptorsBrain slicesTheta frequency oscillationsPharmacological methodsDye imagingCortical oscillationsRole of inhibitionBicucullineDisinhibitionGABAATheta oscillationsCortexBasic spatiotemporal patternsInhibitionNeural information processingCarbacholMental tasksAntagonist
2010
Assimilating Seizure Dynamics
Ullah G, Schiff S. Assimilating Seizure Dynamics. PLOS Computational Biology 2010, 6: e1000776. PMID: 20463875, PMCID: PMC2865517, DOI: 10.1371/journal.pcbi.1000776.Peer-Reviewed Original ResearchConceptsModern control theoryDynamics of networksDynamical systemsControl theoryUnmeasured partDynamical interactionsData assimilationSmall neuronal networksPhysical variablesDynamicsBrain dynamicsComputational modelSeizure dynamicsActual measurementsNeuronal networksMicroenvironment dynamicsObservabilityNetworkVariablesModelTheorySystemMeasurements
2009
Seizure entrainment with polarizing low-frequency electric fields in a chronic animal epilepsy model
Sunderam S, Chernyy N, Peixoto N, Mason J, Weinstein S, Schiff S, Gluckman B. Seizure entrainment with polarizing low-frequency electric fields in a chronic animal epilepsy model. Journal Of Neural Engineering 2009, 6: 046009. PMID: 19602730, PMCID: PMC3057918, DOI: 10.1088/1741-2560/6/4/046009.Peer-Reviewed Original ResearchConceptsField postsynaptic potentialsAnimal epilepsy modelsNeural activitySimultaneous recordingSpontaneous seizuresHippocampal epilepsyVentral hippocampusEpilepsy modelLocal field potentialsPostsynaptic potentialsNeuronal excitabilityNeuronal activityModulatory effectsAnimal modelsSeizuresStatistical significanceStimulationField potentialsMultiple presentationsAnimalsCharacteristic patternEpilepsyHippocampusRecordingsExcitabilityTime dependence of stimulation/recording-artifact transfer function estimates for neural interface systems
Chernyy N, Schiff S, Gluckman B. Time dependence of stimulation/recording-artifact transfer function estimates for neural interface systems. Annual International Conference Of The IEEE Engineering In Medicine And Biology Society (EMBC) 2009, 2009: 1380-1383. PMID: 19964759, PMCID: PMC5502111, DOI: 10.1109/iembs.2009.5334297.Peer-Reviewed Original ResearchConceptsControl systemElectrode interface propertiesLow-frequency electric fieldNeural interface systemInterface propertiesControl outputElectric fieldElectrical potential variationsElectrical currentTransfer function magnitudeImpedance changesSystem stateMeasurement pointsInterface systemFunction magnitudeNeural control systemSimultaneous measurementTime dependencePotential variationPropertiesStimulus artifactTransfer function estimatesSystemFilterCurrent
2008
Multi-taper transfer function estimation for stimulation artifact removal from neural recordings
Chernyy N, Schiff S, Gluckman B. Multi-taper transfer function estimation for stimulation artifact removal from neural recordings. Annual International Conference Of The IEEE Engineering In Medicine And Biology Society (EMBC) 2008, 2008: 2772-2776. PMID: 19163280, PMCID: PMC3547985, DOI: 10.1109/iembs.2008.4649777.Peer-Reviewed Original Research
2007
Dynamical Evolution of Spatiotemporal Patterns in Mammalian Middle Cortex
Schiff S, Huang X, Wu J. Dynamical Evolution of Spatiotemporal Patterns in Mammalian Middle Cortex. Physical Review Letters 2007, 98: 178102. PMID: 17501537, PMCID: PMC2039901, DOI: 10.1103/physrevlett.98.178102.Peer-Reviewed Original ResearchImproved sleep–wake and behavior discrimination using MEMS accelerometers
Sunderam S, Chernyy N, Peixoto N, Mason J, Weinstein S, Schiff S, Gluckman B. Improved sleep–wake and behavior discrimination using MEMS accelerometers. Journal Of Neuroscience Methods 2007, 163: 373-383. PMID: 17481736, PMCID: PMC2279268, DOI: 10.1016/j.jneumeth.2007.03.007.Peer-Reviewed Original Research
2006
Interneuron and Pyramidal Cell Interplay During In Vitro Seizure-Like Events
Ziburkus J, Cressman J, Barreto E, Schiff S. Interneuron and Pyramidal Cell Interplay During In Vitro Seizure-Like Events. Journal Of Neurophysiology 2006, 95: 3948-3954. PMID: 16554499, PMCID: PMC1469233, DOI: 10.1152/jn.01378.2005.Peer-Reviewed Original ResearchSeizure Modulation with Applied Electric Fields in Chronically Implanted Animals
Sunderam S, Chernyy N, Mason J, Peixoto N, Weinstein S, Schiff S, Gluckman B. Seizure Modulation with Applied Electric Fields in Chronically Implanted Animals. Annual International Conference Of The IEEE Engineering In Medicine And Biology Society (EMBC) 2006, 2006: 1612-1615. PMID: 17946910, PMCID: PMC3547984, DOI: 10.1109/iembs.2006.259454.Peer-Reviewed Original Research
2005
Control of Traveling Waves in the Mammalian Cortex
Richardson K, Schiff S, Gluckman B. Control of Traveling Waves in the Mammalian Cortex. Physical Review Letters 2005, 94: 028103. PMID: 15698234, PMCID: PMC1513188, DOI: 10.1103/physrevlett.94.028103.Peer-Reviewed Original Research
2004
Spiral Waves in Disinhibited Mammalian Neocortex
Huang X, Troy W, Yang Q, Ma H, Laing C, Schiff S, Wu J. Spiral Waves in Disinhibited Mammalian Neocortex. Journal Of Neuroscience 2004, 24: 9897-9902. PMID: 15525774, PMCID: PMC4413915, DOI: 10.1523/jneurosci.2705-04.2004.Peer-Reviewed Original Research
2003
Sensitivity of Neurons to Weak Electric Fields
Francis J, Gluckman B, Schiff S. Sensitivity of Neurons to Weak Electric Fields. Journal Of Neuroscience 2003, 23: 7255-7261. PMID: 12917358, PMCID: PMC6740448, DOI: 10.1523/jneurosci.23-19-07255.2003.Peer-Reviewed Original Research