A Murine Model to Study Epilepsy and SUDEP Induced by Malaria Infection
Ssentongo P, Robuccio A, Thuku G, Sim D, Nabi A, Bahari F, Shanmugasundaram B, Billard M, Geronimo A, Short K, Drew P, Baccon J, Weinstein S, Gilliam F, Stoute J, Chinchilli V, Read A, Gluckman B, Schiff S. A Murine Model to Study Epilepsy and SUDEP Induced by Malaria Infection. Scientific Reports 2017, 7: 43652. PMID: 28272506, PMCID: PMC5341121, DOI: 10.1038/srep43652.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsDeath, SuddenDisease Models, AnimalElectroencephalographyEpilepsyMalaria, CerebralMaleMicePlasmodium bergheiSurvival AnalysisConceptsCerebral malariaAnimal modelsStrain combinationsPrevention of epilepsySuch animal modelsSubsequent epilepsyNeurological sequelaeAdjunctive therapyPathophysiological mechanismsMalaria infectionUnexpected deathMurine modelEpilepsyPreclinical researchSUDEPMalariaGenetic backgroundMultiple miceEpileptogenesisSequelaeTherapyInfectionMiceSurvivorsPrevention