2021
Immune activation during Paenibacillus brain infection in African infants with frequent cytomegalovirus co-infection
Isaacs A, Morton S, Movassagh M, Zhang Q, Hehnly C, Zhang L, Morales D, Sinnar S, Ericson J, Mbabazi-Kabachelor E, Ssenyonga P, Onen J, Mulondo R, Hornig M, Warf B, Broach J, Townsend R, Limbrick D, Paulson J, Schiff S. Immune activation during Paenibacillus brain infection in African infants with frequent cytomegalovirus co-infection. IScience 2021, 24: 102351. PMID: 33912816, PMCID: PMC8065213, DOI: 10.1016/j.isci.2021.102351.Peer-Reviewed Original ResearchNeonatal sepsisBrain infectionImmune activationInnate immune system responseRisk of hydrocephalusDominant bacterial pathogenHost immune responsePlatelet-activating factorImmune system responseOxidative stress reactionSecondary sequelaeAdjunctive treatmentImmune response networkNeutrophil activityIL-12Hydrocephalic infantsAfrican infantsIL-13IL-4JAK/STAT pathwayAntigen-presenting complexImmune responseHydrocephalusPotential targetNeuroinflammation
1995
Quinolinic acid in tumors, hemorrhage and bacterial infections of the central nervous system in children
Heyes M, Saito K, Milstien S, Schiff S. Quinolinic acid in tumors, hemorrhage and bacterial infections of the central nervous system in children. Journal Of The Neurological Sciences 1995, 133: 112-118. PMID: 8583213, DOI: 10.1016/0022-510x(95)00164-w.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultBacterial InfectionsBiomarkersBiopterinCentral Nervous System DiseasesCentral Nervous System NeoplasmsCerebral HemorrhageChildChild, PreschoolFemaleGuanosine TriphosphateHumansHydrocephalusInfantInfant, NewbornInterleukin-6KynurenineMaleNeopterinQuinolinic AcidTryptophan OxygenaseTumor Necrosis Factor-alphaConceptsCentral nervous systemQuinolinic acidImmune activationKynurenine pathwayNervous systemBacterial infectionsLevels of QUINCentral nervous system infectionCSF QUIN levelsNervous system infectionCytokine tumor necrosisCNS inflammationNeurological deficitsSystem infectionNeurologic dysfunctionCSF levelsQUIN levelsQUIN concentrationsInterleukin-6Tumor necrosisCerebrospinal fluidNeurotoxic metabolitesSensitive markerMacrophage activationPatients