2023
Use of telemedicine facilitated by trained telepresenters to manage advanced peripheral artery disease in rural areas
Breen T, Peake J, Keefe H, Moran J, Kunjukutty F, Pfau S, Altin S. Use of telemedicine facilitated by trained telepresenters to manage advanced peripheral artery disease in rural areas. Vascular Medicine 2023, 28: 239-240. PMID: 36628596, DOI: 10.1177/1358863x221148797.Peer-Reviewed Original Research
2022
Use of a Novel Catheter, the MOT-C, for Selective Angiography of the Internal Mammary Artery From Ipsilateral Radial Access.
Kunnirickal S, Pfau S, Moran E, Shah S. Use of a Novel Catheter, the MOT-C, for Selective Angiography of the Internal Mammary Artery From Ipsilateral Radial Access. Journal Of Invasive Cardiology 2022, 34: e408-e411. PMID: 35394451, DOI: 10.25270/jic/21.00233.Peer-Reviewed Original ResearchConceptsBypass angiographyInternal mammary arteryContrast volumeFemoral accessRadial accessMammary arteryNovel catheterIpsilateral radial accessLower contrast useCatheter-related complicationsSignificant differencesIMA graftsArtery catheterDiagnostic angiographySelective angiographyDiagnostic angiogramContrast useAngiographyCatheterArteryMinimal manipulationImplementation of supervised exercise therapy in a veteran population with symptomatic claudication
Altin S, Schneider MD, Parise H, Banerjee S, Wu WC, Meadows JL, Pfau S, Keefe H, Armstrong EJ. Implementation of supervised exercise therapy in a veteran population with symptomatic claudication. Vascular Medicine 2022, 27: 136-141. PMID: 35225695, DOI: 10.1177/1358863x211073622.Peer-Reviewed Original ResearchConceptsExercise treadmill testingExercise therapyMetabolic equivalentsIntermittent claudicationExercise capacityTreadmill testingAnkle-brachial indexIntermittent claudication symptomsMale veteran patientsSupervised exercise therapySymptomatic intermittent claudicationVascular specialty clinicsLow patient adherenceClaudication symptomsSymptomatic claudicationExercise groupVeteran patientsPatient adherenceRisk stratificationTherapy referralSpecialty clinicProvider awarenessVeteran populationClaudicationTherapy
2020
The Foundational Role of Cardiovascular Imaging in the Characterization of Mental Stress–Induced Myocardial Ischemia in Patients with Coronary Artery Disease
Meadows JL, Shah S, Burg MM, Pfau S, Soufer R. The Foundational Role of Cardiovascular Imaging in the Characterization of Mental Stress–Induced Myocardial Ischemia in Patients with Coronary Artery Disease. Current Cardiology Reports 2020, 22: 162. PMID: 33037938, DOI: 10.1007/s11886-020-01407-w.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsCoronary artery diseaseArtery diseaseMyocardial ischemiaMental Stress–Induced Myocardial IschemiaNon-obstructive coronary artery diseaseStable coronary artery diseaseHalf of patientsEpicardial coronary stenosisMental stress testingMyocardial oxygen demandUnderstanding of pathophysiologyCoronary macroAnginal symptomsCardiac eventsAdverse prognosisEarly mortalityIschemic phenomenaCoronary perfusionCoronary stenosisCoronary microvasculatureInvasive studiesClinical careMyocardial perfusionStress-mediated changesCardiac responseEffects of Psychological Stress on Vascular Physiology: Beyond the Current Imaging Signal
Shah SM, Meadows JL, Burg MM, Pfau S, Soufer R. Effects of Psychological Stress on Vascular Physiology: Beyond the Current Imaging Signal. Current Cardiology Reports 2020, 22: 156. PMID: 33037500, DOI: 10.1007/s11886-020-01406-x.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsPsychological stressCardiovascular diseaseMental stress-induced myocardial ischemiaStress-induced myocardial ischemiaMental stressVascular smooth muscleMental stress effectsVascular systemCardiovascular imaging modalitiesEntire vascular systemCardiovascular manifestationsVascular effectsMicrovascular resistanceMicrovascular responsesVascular changesVascular mechanismsVascular responsesCardiovascular responsesMyocardial ischemiaLong-term consequencesSmooth muscleMicrovascular compartmentTherapeutic interventionsReviewThis reviewStandardized psychological assessmentsCardiovascular Imaging of Biology and Emotion
Meadows JL, Shah S, Burg MM, Pfau S, Soufer R. Cardiovascular Imaging of Biology and Emotion. Circulation Cardiovascular Imaging 2020, 13: e011054. PMID: 32762255, PMCID: PMC9261020, DOI: 10.1161/circimaging.120.011054.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsMental stressEpicardial coronary artery diseaseCoronary artery diseaseExercise-induced changesMicrovascular dysfunctionArtery diseaseObstructive diseaseClinical manifestationsVascular responsesCentral activationCardiovascular healthPathophysiologic changesCardiovascular responsesMyocardial ischemiaPeripheral vasculatureTreatment targetsVascular pathophysiologyPsychosocial determinantsCardiovascular imagingPsychosocial experiencesImplementation studyMS testingTriggers activationCardiovascular biologyDisease
2018
Heart Failure After Ischemic Stroke or Transient Ischemic Attack in Insulin-Resistant Patients Without Diabetes Mellitus Treated With Pioglitazone
Young LH, Viscoli CM, Schwartz GG, Inzucchi SE, Curtis JP, Gorman MJ, Furie KL, Conwit R, Spatz E, Lovejoy A, Abbott JD, Jacoby DL, Kolansky DM, Ling FS, Pfau SE, Kernan WN. Heart Failure After Ischemic Stroke or Transient Ischemic Attack in Insulin-Resistant Patients Without Diabetes Mellitus Treated With Pioglitazone. Circulation 2018, 138: 1210-1220. PMID: 29934374, PMCID: PMC6202153, DOI: 10.1161/circulationaha.118.034763.Peer-Reviewed Original ResearchConceptsRisk of HFTransient ischemic attackEffect of pioglitazoneHF riskHeart failureInsulin-resistant patientsMyocardial infarctionIschemic attackCardiovascular benefitsIschemic strokeDiabetes mellitusInsulin resistanceHigher C-reactive proteinComposite of strokeHF risk scoreHigher HF riskDrug dose reductionHospitalized heart failureIncident myocardial infarctionLower mean doseC-reactive proteinBaseline patient featuresHF hospitalizationCardiovascular eventsPlacebo groupMultimodality Imaging Involving Magnetic Resonance Facilitates Giant Symptomatic Myxoma Resection
Hur DJ, Prescher LM, Meadows JL, Pfau SE, Homer RJ, Tellides G, Yun JJ. Multimodality Imaging Involving Magnetic Resonance Facilitates Giant Symptomatic Myxoma Resection. The Annals Of Thoracic Surgery 2018, 107: e15-e17. PMID: 30558736, DOI: 10.1016/j.athoracsur.2018.05.083.Peer-Reviewed Case Reports and Technical Notes
2017
Cardiac Outcomes After Ischemic Stroke or Transient Ischemic Attack
Young LH, Viscoli CM, Curtis JP, Inzucchi SE, Schwartz GG, Lovejoy AM, Furie KL, Gorman MJ, Conwit R, Abbott JD, Jacoby DL, Kolansky DM, Pfau SE, Ling FS, Kernan WN. Cardiac Outcomes After Ischemic Stroke or Transient Ischemic Attack. Circulation 2017, 135: 1882-1893. PMID: 28246237, PMCID: PMC5511545, DOI: 10.1161/circulationaha.116.024863.Peer-Reviewed Original ResearchConceptsAcute coronary syndromeType 1 myocardial infarctionTransient ischemic attackMyocardial infarctionCoronary syndromeInsulin resistanceIschemic attackIschemic strokeDiabetes mellitusSerum troponinAcute coronary syndrome episodeMean age 63 yearsAcute coronary syndrome eventIndependent clinical events committeeType 2 myocardial infarctionIRIS participantsImpact of pioglitazoneRecent cerebrovascular eventsRecent ischemic strokeClinical events committeeAge 63 yearsEffect of pioglitazoneSmall myocardial infarctionCoronary artery diseaseST-segment elevation
2016
The Sweatshirt Sign: Coronary Artery Disease
Federman DG, Pfau SE. The Sweatshirt Sign: Coronary Artery Disease. The American Journal Of Medicine 2016, 129: 1267. PMID: 27568344, DOI: 10.1016/j.amjmed.2016.07.025.Peer-Reviewed Original Research
2012
Cellularity and structure of fresh human coronary thrombectomy specimens; presence of cells with markers of progenitor cells
Jovin IS, Lei L, Huang Y, Hao Z, Curtis JP, Brennan JJ, Remetz MS, Setaro JF, Pfau SE, Howes CJ, Clancy JF, Cabin HS, Cleman MW, Giordano FJ. Cellularity and structure of fresh human coronary thrombectomy specimens; presence of cells with markers of progenitor cells. Journal Of Cellular And Molecular Medicine 2012, 16: 3022-3027. PMID: 22947374, PMCID: PMC4393730, DOI: 10.1111/j.1582-4934.2012.01629.x.Peer-Reviewed Original ResearchConceptsAcute coronary syndromeCoronary thrombectomyCoronary syndromeProgenitor cellsCholesterol crystalsAcute myocardial infarctionEndothelial progenitor cellsFormation of thrombiHaematopoietic progenitor cellsVon Willebrand factorInflammatory cellsEndothelial cell mediumMyocardial infarctionPlaque ruptureThrombectomyImmunohistochemical analysisVascular wallPresence of cellsBlood cellsWillebrand factorThrombusRecovery of left ventricular function after percutaneous revascularization of a left main chronic total occlusion
Khanna P, Stilp E, Pfau S. Recovery of left ventricular function after percutaneous revascularization of a left main chronic total occlusion. Catheterization And Cardiovascular Interventions 2012, 80: 310-315. PMID: 22553190, DOI: 10.1002/ccd.24322.Peer-Reviewed Original ResearchMeSH KeywordsAgedCardiomyopathy, DilatedChronic DiseaseCoronary AngiographyCoronary OcclusionDrug-Eluting StentsHumansMaleMyocardial Perfusion ImagingPercutaneous Coronary InterventionPositron-Emission TomographyRecovery of FunctionStroke VolumeTreatment OutcomeVentricular Dysfunction, LeftVentricular Function, LeftConceptsLeft ventricular ejection fractionPercutaneous coronary interventionCoronary artery diseaseMain percutaneous coronary interventionChronic total occlusionSurgical revascularizationTotal occlusionThree-vessel coronary artery diseaseDepressed left ventricular ejection fractionMultivessel coronary artery diseaseMultivessel percutaneous coronary interventionIntermediate-term mortalityLeft ventricular dysfunctionVentricular ejection fractionLeft ventricular functionLeft ventricular sizeComplete revascularizationPercutaneous revascularizationTerm mortalityVentricular dysfunctionCoronary interventionArtery diseaseEjection fractionImproved survivalMedical therapy
2009
Interleukin-17 and Interferon-γ Are Produced Concomitantly by Human Coronary Artery–Infiltrating T Cells and Act Synergistically on Vascular Smooth Muscle Cells
Eid RE, Rao DA, Zhou J, Lo SF, Ranjbaran H, Gallo A, Sokol SI, Pfau S, Pober JS, Tellides G. Interleukin-17 and Interferon-γ Are Produced Concomitantly by Human Coronary Artery–Infiltrating T Cells and Act Synergistically on Vascular Smooth Muscle Cells. Circulation 2009, 119: 1424-1432. PMID: 19255340, PMCID: PMC2898514, DOI: 10.1161/circulationaha.108.827618.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedCD4-Positive T-LymphocytesCells, CulturedChemokine CXCL10Coronary Artery DiseaseCoronary VesselsFemaleGene Expression RegulationHumansInflammation MediatorsInterferon-gammaInterleukin-17Interleukin-6Interleukin-8InterleukinsMaleMiddle AgedMuscle, Smooth, VascularMyocytes, Smooth MuscleReceptors, InterferonReceptors, Interleukin-17Signal TransductionT-Lymphocyte SubsetsTransforming Growth Factor beta1VasculitisConceptsVascular smooth muscle cellsSmooth muscle cellsIL-17IFN-gammaT cellsCoronary atherosclerosisMuscle cellsCoronary arteryIL-6Signature cytokinesIL-17 plasma levelsCultured vascular smooth muscle cellsIL-17 synthesisIL-17 responsesHuman coronary atherosclerosisIL-17 secretionSubset of patientsIL-17 producersT helper cellsIFN-gamma synthesisIFN-gamma producersYoung healthy individualsAtherosclerotic coronary arteriesHuman coronary arteriesTh17 cells
2007
An Inflammatory Pathway of IFN-γ Production in Coronary Atherosclerosis
Ranjbaran H, Sokol SI, Gallo A, Eid RE, Iakimov AO, D’Alessio A, Kapoor JR, Akhtar S, Howes CJ, Aslan M, Pfau S, Pober JS, Tellides G. An Inflammatory Pathway of IFN-γ Production in Coronary Atherosclerosis. The Journal Of Immunology 2007, 178: 592-604. PMID: 17182600, DOI: 10.4049/jimmunol.178.1.592.Peer-Reviewed Original ResearchConceptsIL-12/ILIFN-gamma-inducible chemokinesCoronary atherosclerosisIL-12IL-18IFN-gammaPlasma levelsT cellsTh1-type cytokine productionHuman atherosclerotic coronary arteriesAcute coronary syndromeSubset of patientsHuman coronary atherosclerosisTh1-type cytokinesC-reactive proteinIFN-γ productionElevated plasma levelsPlasma of patientsInnate immune responseAtherosclerotic coronary arteriesCoronary syndromeSystemic inflammationCardiac catheterizationCardiopulmonary bypassGamma secretion
2003
Brachytherapy for in-stent restenosis in general interventional practice A single institution's experience using four radiation devices
Singh HS, Roberts KB, Yue N, Nath R, Song GH, Azimi N, Pfau S. Brachytherapy for in-stent restenosis in general interventional practice A single institution's experience using four radiation devices. Cardiovascular Revascularization Medicine 2003, 4: 126-132. PMID: 14984712, DOI: 10.1016/s1522-1865(03)00183-5.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAged, 80 and overAngioplasty, Balloon, CoronaryBlood Vessel Prosthesis ImplantationBrachytherapyConnecticutCoronary AngiographyCoronary Artery BypassCoronary RestenosisCoronary StenosisEquipment DesignFamily PracticeFemaleFollow-Up StudiesHospital MortalityHumansMaleMiddle AgedRadiation DosageReoperationRetrospective StudiesStentsTreatment OutcomeConceptsMajor adverse cardiac eventsStent restenosisAverage treatment ageEffectiveness of brachytherapyAdverse cardiac eventsSingle institution experienceMinimal lumen diameterRandomized clinical trialsLesion-specific characteristicsSpectrum of patientsMACE rateHospital deathCardiac eventsRenal failureUnstable anginaClinical outcomesCoronary lesionsTreatment failureInstitution experienceFrequent presentationInterventional therapyClinical trialsGeneral populationInterventional practicePatientsDose distributions in bifurcated coronary vessels treated with catheter‐based photon and beta emitters in intravascular brachytherapy
Yue N, Roberts KB, Pfau SE, Nath R. Dose distributions in bifurcated coronary vessels treated with catheter‐based photon and beta emitters in intravascular brachytherapy. Medical Physics 2003, 30: 1628-1636. PMID: 12906180, DOI: 10.1118/1.1582813.Peer-Reviewed Original ResearchElectromechanical mapping for detecting myocardial viability and ischemia in patients with severe ischemic cardiomyopathy
Samady H, Liu Y, Choi CJ, Ragosta M, Pfau SE, Cleman MW, Powers ER, Kramer CM, Wackers F, Beller GA, Watson DD. Electromechanical mapping for detecting myocardial viability and ischemia in patients with severe ischemic cardiomyopathy. The American Journal Of Cardiology 2003, 91: 807-811. PMID: 12667565, DOI: 10.1016/s0002-9149(03)00013-4.Peer-Reviewed Original ResearchMeSH KeywordsAgedBody Surface Potential MappingCardiomyopathiesCell SurvivalElectrophysiologic Techniques, CardiacFemaleHumansMaleMiddle AgedMyocardial IschemiaMyocardiumPredictive Value of TestsRadiopharmaceuticalsRestROC CurveSensitivity and SpecificitySeverity of Illness IndexStatistics as TopicStress, PhysiologicalStroke VolumeTechnetium Tc 99m SestamibiTomography, Emission-Computed, Single-PhotonVentricular Dysfunction, LeftConceptsSevere ischemic cardiomyopathyIschemic cardiomyopathyViable myocardiumMyocardial viabilityDipyridamole single-photon emissionUnipolar voltageDysfunctional myocardial segmentsBipolar voltageSingle photon emissionDipyridamole SPECTDipyridamole technetiumQuantitative technetiumInducible ischemiaNonviable segmentsNonviable myocardiumElectromechanical mappingMyocardial segmentsTracer uptakePatientsViable segmentsLogistic regressionCardiomyopathyMyocardiumIschemiaSPECT
2001
Effect of Non–Insulin-Dependent Diabetes Mellitus on Myocardial Insulin Responsiveness in Patients With Ischemic Heart Disease
Jagasia D, Whiting J, Concato J, Pfau S, McNulty P. Effect of Non–Insulin-Dependent Diabetes Mellitus on Myocardial Insulin Responsiveness in Patients With Ischemic Heart Disease. Circulation 2001, 103: 1734-1739. PMID: 11282903, DOI: 10.1161/01.cir.103.13.1734.Peer-Reviewed Original ResearchConceptsGlucose uptakeMyocardial insulin responsivenessCoronary disease patientsCoronary blood flowDependent diabetes mellitusIschemic heart diseaseMyocardium of patientsPoor clinical outcomeNet lactate uptakeCardiac glucose uptakeFractional extractionClinical outcomesDiabetes mellitusNon-InsulinInsulin levelsInsulin resistanceCardiac responsivenessDisease patientsInsulin infusionHeart diseaseMyocardial ischemiaPeripheral tissuesGlucose levelsBlood flowArterial plasmaSerum complement activation in congestive heart failure
Clark D, Cleman M, Pfau S, Rollins S, Ramahi T, Mayer C, Caulin-Glaser T, Daher E, Kosiborod M, Bell L, Setaro J. Serum complement activation in congestive heart failure. American Heart Journal 2001, 141: 684-690. PMID: 11275938, DOI: 10.1067/mhj.2001.113758.Peer-Reviewed Original ResearchConceptsCongestive heart failureSymptomatic heart failureC5b-9 levelsHeart failureClinical outcomesC5b-9Control patientsNew York Heart Association class IV symptomsComplement activationAge-matched control patientsClass IV symptomsCombined clinical outcomeAdverse clinical outcomesVentricular ejection fractionTerminal complement complex C5b-9Terminal complement activationComplement complex C5b-9Serum complement activationTerminal complement complexAdverse eventsCardiopulmonary bypassEjection fractionSerum levelsMyocardial injuryMyocardial infarction
2000
Myocardial blood-flow response during mental stress in patients with coronary artery disease
Arrighi J, Burg M, Cohen I, Kao A, Pfau S, Caulin-Glaser T, Zaret B, Soufer R. Myocardial blood-flow response during mental stress in patients with coronary artery disease. The Lancet 2000, 356: 310-311. PMID: 11071190, DOI: 10.1016/s0140-6736(00)02510-1.Peer-Reviewed Original Research